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We conducted Mendelian randomization analyses where genetic variants indexed expected effects of modulating lipid\u2010lowering drug targets on PD. Statin exposure was not predicted to increase PD risk, although results were not precise enough to support benefits for prevention clearly (odds ratio [OR] =\u20090.83; 95% confidence interval [CI] =\u20090.65, 1.07). Other target results were null, except for variants indicating Apolipoprotein\u2010A5 or Apolipoprotein\u2010C3 inhibition might confer protection. These findings suggest peripheral lipid variation may not have a prominent role in PD etiology, but some related drug targets could influence PD via alternate pathways. 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