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All but 1 had Pittsburgh compound B (PiB)\u2010PET. Braak staging, A\u03b2 plaque and neurofibrillary tangle counts, and semiquantitative tau lesion scores were performed. Flortaucipir standard uptake value ratios (SUVRs) were calculated in a temporal meta region of interest (meta\u2010ROI), entorhinal cortex and cortical\/subcortical regions selected to match the tau lesion analysis. Global PiB SUVR was calculated. Autoradiography was performed in 1 PSP patient, with digital pathology used to quantify tau burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine cases (37.5%) had A\u03b2 plaques. Global PiB SUVR correlated with A\u03b2 plaque count, with 100% specificity and 50% sensitivity for diffuse plaques. Twenty\u2010one (87.5%) had Braak stages I to IV. Flortaucipir correlated with neurofibrillary tangle counts in entorhinal cortex, but entorhinal and meta\u2010ROI SUVRs were not elevated in Braak IV or primary age\u2010related tauopathy. Flortaucipir uptake patterns differed across FTLD pathologies and could separate PSP and CBD. Flortaucipir correlated with tau lesion score in red nucleus and midbrain tegmentum across patients, but not in cortical or basal ganglia regions. Autoradiography demonstrated minimal uptake of flortaucipir, although flortaucipir correlated with quantitative tau burden across regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Molecular PET shows expected correlations with Alzheimer\u2010related pathology but lacks sensitivity to detect mild Alzheimer pathology in FTLD. Regional flortaucipir uptake was able to separate CBD and PSP. ANN NEUROL 2020;88:1009\u20131022<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.25893","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T05:13:57Z","timestamp":1598937237000},"page":"1009-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Sensitivity\u2013Specificity of Tau and Amyloid \u03b2 Positron Emission Tomography in Frontotemporal Lobar Degeneration"],"prefix":"10.1002","volume":"88","author":[{"given":"Alma","family":"Ghirelli","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirubol","family":"Tosakulwong","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic  Rochester Minnesota 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