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This study aimed to investigate the role of intermediate\u2010length <jats:italic>NOTCH2NLC<\/jats:italic> GGC repeat expansions in Parkinson disease (PD). We screened for GGC repeat expansions in a cohort of 1,011 PD patients and identified 11 patients with intermediate\u2010length repeat expansions ranging from 41 to 52 repeats, with no repeat expansions in 1,134 controls. Skin biopsy revealed phospho\u2010alpha\u2010synuclein deposition, confirming the PD diagnosis in 2 patients harboring intermediate\u2010length repeat expansions instead of NIID or essential tremor. Fibroblasts from PD patients harboring intermediate\u2010length repeat expansions revealed <jats:italic>NOTCH2NLC<\/jats:italic> upregulation and autophagic dysfunction. Our results suggest that intermediate\u2010length repeat expansions in <jats:italic>NOTCH2NLC<\/jats:italic> are potentially associated with PD. 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