{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:07:53Z","timestamp":1790129273040,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to gain insights into structural networks associated with stimulation\u2010induced dysarthria (SID) and to predict stimulation\u2010induced worsening of intelligibility in essential tremor patients with bilateral thalamic deep brain stimulation (DBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Monopolar reviews were conducted in 14 essential tremor patients. Testing included determination of SID thresholds, intelligibility ratings, and a fast syllable repetition task. Volumes of tissue activated (VTAs) were calculated to identify discriminative fibers for stimulation\u2010induced worsening of intelligibility in a structural connectome. The resulting fiber\u2010based atlas structure was then validated in a leave\u2010one\u2010out design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fibers determined as discriminative for stimulation\u2010induced worsening of intelligibility were mainly connected to the ipsilateral precentral gyrus as well as to both cerebellar hemispheres and the ipsilateral brain stem. In the thalamic area, they ran laterally to the thalamus and posteromedially to the subthalamic nucleus, in close proximity, mainly anterolaterally, to fibers beneficial for tremor control as published by Al\u2010Fatly et al in 2019. The overlap of the respective clinical stimulation setting's VTAs with these fibers explained 62.4% (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.001) of the variance of stimulation\u2010induced change in intelligibility in a leave\u2010one\u2010out analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>This study demonstrates that SID in essential tremor patients is associated with both motor cortex and cerebellar connectivity. Furthermore, the identified fiber\u2010based atlas structure might contribute to future postoperative programming strategies to achieve optimal tremor control without speech impairment in essential tremor patients with thalamic DBS. ANN NEUROL 2021;89:315\u2013326<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.25958","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:49:37Z","timestamp":1605602977000},"page":"315-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Network Fingerprint of Stimulation\u2010Induced Speech Impairment in Essential Tremor"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-3840","authenticated-orcid":false,"given":"Jan Niklas","family":"Petry\u2010Schmelzer","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Jergas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital 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