{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:18:18Z","timestamp":1790691498687,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000374","name":"British Medical Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000295","name":"Epilepsy Research UK","doi-asserted-by":"publisher","award":["P1201"],"award-info":[{"award-number":["P1201"]}],"id":[{"id":"10.13039\/501100000295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/V007173\/1"],"award-info":[{"award-number":["MR\/V007173\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104079\/Z\/14\/Z"],"award-info":[{"award-number":["104079\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    Pain is a under\u2010recognized association of leucine\u2010rich glioma\u2010inactivated 1 (LGI1) and contactin\u2010associated protein\u2010like 2 (CASPR2) antibodies. Of 147 patients with these autoantibodies, pain was experienced by 17 of 33 (52%) with CASPR2\u2010 versus 20 of 108 (19%) with LGI1 antibodies (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.0005), and identified as neuropathic in 89% versus 58% of these, respectively. Typically, in both cohorts, normal nerve conduction studies and reduced intraepidermal nerve fiber densities were observed in the sampled patient subsets. In LGI1 antibody patients, pain responded to immunotherapy (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.008), often rapidly, with greater residual patient\u2010rated impairment observed in CASPR2 antibody patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.019). Serum CASPR2 antibodies, but not LGI1 antibodies, bound in vitro to unmyelinated human sensory neurons and rodent dorsal root ganglia, suggesting pathophysiological differences that may underlie our clinical observations. ANN NEUROL 2021;90:683\u2013690\n                  <\/jats:p>","DOI":"10.1002\/ana.26189","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T15:43:34Z","timestamp":1628523814000},"page":"683-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Leucine\u2010Rich Glioma\u2010Inactivated 1 versus Contactin\u2010Associated Protein\u2010like 2 Antibody Neuropathic Pain: Clinical and Biological Comparisons"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-9768","authenticated-orcid":false,"given":"Sudarshini","family":"Ramanathan","sequence":"first","affiliation":[{"name":"Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital University of Oxford  Oxford UK"},{"name":"Neuroimmunology and Brain Autoimmunity Groups, Kids Neuroscience Centre, Children's Hospital at Westmead; Brain and Mind Centre 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