{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:44:09Z","timestamp":1768531449794,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23NS084054"],"award-info":[{"award-number":["K23NS084054"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AI 060354"],"award-info":[{"award-number":["P30AI 060354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>We conducted a prospective cohort study to determine the prevalence of leukotriene A4 hydrolase (<jats:italic>LTA4H<\/jats:italic>) polymorphisms in Zambian adults with tuberculous meningitis (TBM) and its association with mortality. We completed genotype testing on 101 definite cases of TBM and 119 consecutive non\u2010TBM controls. The distribution of genotypes among TBM patients was as follows: C\/C (0.83), C\/T (0.14), T\/T (0.03). There was no significant difference in genotype distribution between TBM and non\u2010TBM patients. We found no relationship between <jats:italic>LTA4H<\/jats:italic> polymorphism and survival. Prospective studies are needed to determine the benefit of adjuvant steroids in TBM based upon population <jats:italic>LTA4H<\/jats:italic> genotype. ANN NEUROL 2021;90:994\u2013998<\/jats:p>","DOI":"10.1002\/ana.26240","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T03:41:32Z","timestamp":1633059692000},"page":"994-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp><i>LTA4H<\/i><\/scp> Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9696-563X","authenticated-orcid":false,"given":"Omar K.","family":"Siddiqi","sequence":"first","affiliation":[{"name":"Global Neurology Program, Department of Neurology Beth Israel Deaconess Medical Center  Boston MA"},{"name":"Department of Internal Medicine, Center for Vaccines and Virology Research Beth Israel Deaconess Medical Center  Boston MA"},{"name":"Department of Internal Medicine University of Zambia School of Medicine  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musie","family":"Ghebremichael","sequence":"additional","affiliation":[{"name":"Harvard Medical School and Ragon Institute of MGH, MIT, and Harvard  Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalo","family":"Musukuma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Zambia School of Medicine  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Dang","sequence":"additional","affiliation":[{"name":"Ken &amp; Ruth Davee Department of Neurology Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Mubanga","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Zambia School of Medicine  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretchen L.","family":"Birbeck","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rochester  Rochester NY"},{"name":"University Teaching Hospital Neurology Research Office  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"Love","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, Los Angeles  Los Angeles CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clayton","family":"Buback","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California, San Francisco  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Kosloff","sequence":"additional","affiliation":[{"name":"Zambart  Lusaka Zambia"},{"name":"London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Ayles","sequence":"additional","affiliation":[{"name":"Zambart  Lusaka Zambia"},{"name":"London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masharip","family":"Atadzhanov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Zambia School of Medicine  Lusaka Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6836-1468","authenticated-orcid":false,"given":"Igor J.","family":"Koralnik","sequence":"additional","affiliation":[{"name":"Ken &amp; Ruth Davee Department of Neurology Northwestern University Feinberg School of Medicine  Chicago IL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7060-6"},{"key":"e_1_2_8_3_1","unstructured":"UNAIDSZambia. 2018. 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