{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:48:55Z","timestamp":1791528535271,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG047644"],"award-info":[{"award-number":["AG047644"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014761","name":"Hope Center for Neurological Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p><jats:italic>APOE<\/jats:italic> is the strongest genetic factor for late\u2010onset Alzheimer's disease (AD). A specific conformation of the ApoE protein is present in amyloid\u2010\u03b2 (A\u03b2) containing plaques. Immunotherapy targeting ApoE in plaques reduces brain A\u03b2 deposits in mice. Here, we evaluated the effects of the anti\u2010human APOE antibody HAE\u20104 on amyloid plaques, A\u03b2\u2010mediated tau seeding and spreading, and neuritic dystrophy in the 5XFAD amyloid mice expressing human ApoE4. HAE\u20104 reduced A\u03b2 plaques as well as A\u03b2\u2010driven tau seeding\/spreading and neuritic dystrophy. These results demonstrate that HAE\u20104 may provide therapeutic effects on amyloid removal and A\u03b2 driven downstream consequences such as tauopathy. ANN NEUROL 2022;91:847\u2013852<\/jats:p>","DOI":"10.1002\/ana.26351","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T04:33:30Z","timestamp":1647232410000},"page":"847-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["APOE Antibody Inhibits A\u03b2\u2010Associated Tau Seeding and Spreading in a Mouse Model"],"prefix":"10.1002","volume":"91","author":[{"given":"Maud","family":"Gratuze","sequence":"first","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center Washington University School of 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