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In a subset of 10 patients, EEG analysis and individualized modelling of electric field distribution were carried out. Predictors to \u03b3\u2010tACS efficacy were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a significant improvement in the Rey Auditory Verbal Learning (RAVL) test immediate recall (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) and delayed recall scores (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) after \u03b3\u2010tACS but not after sham tACS. Face\u2010name associations scores improved with \u03b3\u2010tACS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) but not after sham tACS. Short latency afferent inhibition, an indirect measure of cholinergic transmission, increased only after \u03b3\u2010tACS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001).<jats:italic>ApoE<\/jats:italic>genotype and baseline cognitive impairment were the best predictors of response to \u03b3\u2010tACS. Clinical improvement correlated with the increase in gamma frequencies in posterior regions and with the amount of predicted electric field distribution in the precuneus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Precuneus \u03b3\u2010tACS, able to increase \u03b3\u2010power activity on the posterior brain regions, showed a significant improvement of episodic memory performances, along with restoration of intracortical excitability measures of cholinergic transmission. Response to \u03b3\u2010tACS was dependent on genetic factors and disease stage. 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