{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:11:12Z","timestamp":1791490272597,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["423924\/2016\u20108"],"award-info":[{"award-number":["423924\/2016\u20108"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2015\/14231\u20100"],"award-info":[{"award-number":["2015\/14231\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Rehabilitation top\u2010down techniques based on brain stimulation present variable outcomes in unilateral spatial neglect (USN) after stroke. This study aimed to examine the effects of physical therapy after anodal and cathodal transcranial direct current stimulation (A\u2010tDCS and C\u2010tDCS, respectively) to improve visuospatial and functional impairments in individuals with USN after stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010blinded, pilot randomized clinical trial enrolled patients with USN after ischemic stroke. Randomization was stratified according to the Behavior Inattention Test\u2013Conventional (BIT\u2010C) and Catherine Bergego Scale (CBS). Outpatient physical therapy was conducted for 7.5\u2009weeks after 20\u2009minutes of tDCS. The primary outcome was the USN degree evaluated by the BIT\u2010C. Secondary outcomes were the difference in CBS score, stroke severity (National Institutes of Health Stroke Scale [NIHSS]), disability (modified Rankin Scale), autonomy (Barthel Index, Functional Independence Measure), and quality of life (EuroQol Group 5\u2010Dimension Self\u2010Report Questionnaire). Outcomes were analyzed using an analysis of covariance model corrected by age, baseline NIHSS, and baseline BIT\u2010C. Pairwise post hoc comparisons were performed using Bonferroni correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the primary outcomes, A\u2010tDCS led to greater improvement in BIT\u2010C after intervention (mean difference [MD]\u00a0=\u200918.4, 95% confidence interval [CI]\u00a0=\u20093.9\u201332.8, <jats:italic>p<\/jats:italic>\u00a0=\u20090.008) compared to sham. However, no significant differences were observed between A\u2010tDCS and C\u2010tDCS (MD\u00a0=\u00a013.9, 95% CI\u00a0=\u00a0\u22120.3 to 28.1, <jats:italic>p<\/jats:italic>\u00a0=\u20090.057), or C\u2010tDCS and sham (MD\u00a0=\u00a04.5, 95% CI\u00a0=\u00a0\u22129.7 to 18.8, <jats:italic>p<\/jats:italic>\u00a0=\u20090.99). There were no significant differences between groups in terms of secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>A\u2010tDCS associated with physical therapy can decrease the severity of USN after stroke. However, these preliminary findings must be confirmed by collecting additional evidence in a larger phase 3 trial. ANN NEUROL 2022;92:400\u2013410<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.26430","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T02:43:24Z","timestamp":1654915404000},"page":"400-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Non\u2010invasive Brain Stimulation Can Reduce Unilateral Spatial Neglect after Stroke: <scp>ELETRON<\/scp> Trial"],"prefix":"10.1002","volume":"92","author":[{"given":"Ta\u00eds Regina","family":"da Silva","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Botucatu Medical School, S\u00e3o Paulo State University (UNESP)  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio Rubens","family":"de Carvalho Nunes","sequence":"additional","affiliation":[{"name":"Department of Public Health Botucatu Medical School, S\u00e3o Paulo State University (UNESP)  Botucatu 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