{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:10:56Z","timestamp":1787724656739,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F30\u2010AG063440"],"award-info":[{"award-number":["F30\u2010AG063440"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30\u2010AG062429"],"award-info":[{"award-number":["P30\u2010AG062429"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Primary age\u2010related tauopathy (PART) refers to tau neurofibrillary tangles restricted largely to the medial temporal lobe in the absence of significant beta\u2010amyloid plaques. PART has been associated with cognitive impairment, but contributions from concomitant limbic age\u2010related TDP\u201043 encephalopathy neuropathologic change (LATE\u2010NC) are underappreciated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compare prevalence of LATE\u2010NC and vascular copathologies in age\u2010 and Braak\u2010matched patients with PART (n\u00a0=\u00a045, Braak stage I\u2013IV, Thal phase 0\u20132) or early stage Alzheimer disease neuropathologic change (ADNC; n\u00a0=\u00a051, Braak I\u2013IV, Thal 3\u20135), and examine their influence on clinical and cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Concomitant LATE\u2010NC and vascular pathology were equally common, and cognition was equally impaired, in PART (Mini\u2010Mental State Examination [MMSE]\u00a0=\u00a024.8\u00a0\u00b1\u20096.9) and ADNC (MMSE\u00a0=\u00a024.2\u00a0\u00b1\u20096.0). Patients with LATE\u2010NC were more impaired than those without LATE\u2010NC on the MMSE (by 5.8 points, 95% confidence interval [CI] =\u20093.0\u20138.6), Mattis Dementia Rating Scale (DRS; 17.5 points, 95% CI\u00a0=\u00a07.1\u201327.9), Clinical Dementia Rating, sum of boxes scale (CDR\u2010sob; 5.2 points, 95% CI\u00a0=\u00a02.1\u20138.2), memory composite (0.8 standard deviations [SD], 95% CI\u00a0=\u00a00.1\u20131.6), and language composite (1.1 SD, 95% CI\u00a0=\u00a00.2\u20132.0), and more likely to receive a dementia diagnosis (odds ratio\u00a0=\u00a04.8, 95% CI\u00a0=\u00a01.5\u201318.0). Those with vascular pathology performed worse than those without on the DRS (by 10.2 points, 95% CI\u00a0=\u00a00.1\u201320.3) and executive composite (1.3 SD, 95% CI\u00a0=\u00a00.3\u20132.3). Cognition declined similarly in PART and ADNC over the 5\u2009years preceding death; however, LATE\u2010NC was associated with more rapid decline on the MMSE (\u03b2\u00a0=\u00a01.9, 95% CI\u00a0=\u00a00.9\u20133.0), DRS (\u03b2\u00a0=\u00a07.8, 95% CI\u00a0=\u00a03.4\u201312.7), CDR\u2010sob (\u03b2\u00a0=\u00a01.9, 95% CI\u00a0=\u00a00.4\u20133.7), language composite (\u03b2\u00a0=\u00a00.5 SD, 95% CI\u00a0=\u00a00.1\u20130.8), and vascular pathology with more rapid decline on the DRS (\u03b2\u00a0=\u00a05.2, 95% CI\u00a0=\u00a00.6\u201310.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>LATE\u2010NC, and to a lesser extent vascular copathology, exacerbate cognitive impairment and decline in PART and early stage ADNC. ANN NEUROL 2022;92:425\u2013438<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.26438","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T15:13:20Z","timestamp":1655133200000},"page":"425-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["<scp>TDP<\/scp>\n                    \u201043 Pathology Exacerbates Cognitive Decline in Primary\n                    <scp>Age\u2010Related<\/scp>\n                    Tauopathy"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9768-313X","authenticated-orcid":false,"given":"Denis S.","family":"Smirnov","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of California, San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Salmon","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California, San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Galasko","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California, San Diego  San Diego California"},{"name":"Veterans Affairs San Diego Healthcare System  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Edland","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of California, San Diego  San Diego California"},{"name":"School of Public Health University of California, San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"Pizzo","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California, San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Goodwill","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California, San Diego  San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Hiniker","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California, San Diego  San Diego 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