{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:33:50Z","timestamp":1783654430655,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Despite a 90% reperfusion rate, only 50% of patients with anterior circulation large vessel occlusion\u2010related acute ischemic stroke (LVO\u2010AIS) have a functional recovery at 3\u2009months. Parenchymal hematoma (PH) is a predictor of poor outcome after endovascular treatment (EVT). We aim to investigate the relationship between the delay from onset to reperfusion, the occurrence of PH, and functional outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Endovascular Treatment in Ischemic Stroke (ETIS) registry is an ongoing prospective observational study. Data were analyzed from the subgroup of patients who underwent a successful EVT defined by a modified Thrombolysis in Cerebral Infarction (mTICI) score 2b\u20103. We assessed the factors associated with PH, (ie, PH1 or PH2 grade according to the European Collaborative Acute Stroke Study 2 (ECASS) classification of hemorrhagic transformation), then evaluated the relationships between PH, delay from onset to reperfusion, and functional recovery defined by a modified Rankin Scale (mRS) of 0\u20132.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 2,919 patients with an LVO\u2010related AIS who underwent a successful EVT. Overall, 13.3% of the participant experienced a PH. The rate of PH increased by 2.5% (95% CI 1.5%\u20133.6%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) for every additional hour of onset to reperfusion delay and was, by comparison with the other study patients, consistently associated with a lower rate of functional recovery 19.7% (95% CI 11.6%\u201327.7%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) irrespective of time from onset to reperfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our results demonstrate that PH rate is associated with the delay from onset to reperfusion and participates in the relationship between time to reperfusion and outcome. Time is Bleeding. ANN NEUROL 2022;92:882\u2013887<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.26478","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T03:45:21Z","timestamp":1660794321000},"page":"882-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Parenchymal Hemorrhage Rate Is Associated with Time to Reperfusion and Outcome"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-2276","authenticated-orcid":false,"given":"Jean\u2010Marc","family":"Olivot","sequence":"first","affiliation":[{"name":"Department of Neurology Acute Stroke Unit\u2010CIC 1436\u2010UMR 1214, CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanos","family":"Finitsis","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Aristotle University of Thessaloniki, Ahepa Hospital  Thessaoniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Lapergue","sequence":"additional","affiliation":[{"name":"Department of Neurology Foch Hospital, Versailles Saint\u2010Quentin en Yvelines University  Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaultier","family":"Marnat","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University Hospital of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Sibon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Center University Hospital of Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stroke Unit Universit\u00e9 de Lorraine, CHRU\u2010Nancy  Nancy France"},{"name":"Clinical investigation center CIC\u2010P 1433, INSERM U1116, CHRU\u2010Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Viguier","sequence":"additional","affiliation":[{"name":"Department of Neurology Acute Stroke Unit\u2010CIC 1436\u2010UMR 1214, CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Cognard","sequence":"additional","affiliation":[{"name":"Department of Interventional and Diagnostic Neuroradiolology CHU Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Mazighi","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology FHU Neurovasc, INSERM 1148, Universit\u00e9 de Paris Cit\u00e9, Rothschild Foundation  Paris 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