{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:40:00Z","timestamp":1792485600010,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Vici Grant 918.16.616"],"award-info":[{"award-number":["Vici Grant 918.16.616"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017271","name":"Stiftung zur Erforschung der Vaskul\u00e4ren Demenz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cerebral small vessel diseases (cSVDs) are a major cause of stroke and dementia. We used cutting\u2010edge 7T\u2010MRI techniques in patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), to establish which aspects of cerebral small vessel function are affected by this monogenic form of cSVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 23 CADASIL patients (age 51.1\u2009\u00b1\u200910.1\u2009years, 52% women) and 13 age\u2010 and sex\u2010matched controls (46.1\u2009\u00b1\u200912.6, 46% women). Small vessel function measures included: basal ganglia and centrum semiovale perforating artery blood flow velocity and pulsatility, vascular reactivity to a visual stimulus in the occipital cortex and reactivity to hypercapnia in the cortex, subcortical gray matter, white matter, and white matter hyperintensities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with controls, CADASIL patients showed lower blood flow velocity and higher pulsatility index within perforating arteries of the centrum semiovale (mean difference\u2009\u2212\u20090.09\u2009cm\/s,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03 and 0.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009) and basal ganglia (mean difference\u2009\u2212\u20090.98\u2009cm\/s,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003 and 0.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.06). Small vessel reactivity to a short visual stimulus was decreased (blood\u2010oxygen\u2010level dependent [BOLD] mean difference\u2009\u22120.21%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04) in patients, while reactivity to hypercapnia was preserved in the cortex, subcortical gray matter, and normal appearing white matter. Among patients, reactivity to hypercapnia was decreased in white matter hyperintensities compared to normal appearing white matter (BOLD mean difference\u2009\u22120.29%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Multiple aspects of cerebral small vessel function on 7T\u2010MRI were abnormal in CADASIL patients, indicative of increased arteriolar stiffness and regional abnormalities in reactivity, locally also in relation to white matter injury. These observations provide novel markers of cSVD for mechanistic and intervention studies. ANN NEUROL 2023;93:29\u201339<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.26527","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T08:19:10Z","timestamp":1665562750000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["<scp>CADASIL<\/scp>\n                    Affects Multiple Aspects of Cerebral Small Vessel Function on\n                    <scp>7T\u2010MRI<\/scp>"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-0274","authenticated-orcid":false,"given":"Hilde","family":"van den Brink","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5037-2342","authenticated-orcid":false,"given":"Anna","family":"Kopczak","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research University Hospital, Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-7737","authenticated-orcid":false,"given":"Tine","family":"Arts","sequence":"additional","affiliation":[{"name":"Department of Radiology, Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurien","family":"Onkenhout","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-2868","authenticated-orcid":false,"given":"Jeroen C.W.","family":"Siero","sequence":"additional","affiliation":[{"name":"Department of Radiology, Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Spinoza Centre for Neuroimaging Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-5719","authenticated-orcid":false,"given":"Jaco J.M.","family":"Zwanenburg","sequence":"additional","affiliation":[{"name":"Department of Radiology, Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hein","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research University Hospital, Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research University Hospital, Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno","family":"Gesierich","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research University Hospital, Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"},{"name":"Medical Image Analysis Center (MIAC AG) and qbig, Department of Biomedical Engineering University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2302-3136","authenticated-orcid":false,"given":"Marco","family":"Duering","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research University Hospital, Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"},{"name":"Medical Image Analysis Center (MIAC AG) and qbig, Department of Biomedical Engineering University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-4439","authenticated-orcid":false,"given":"Michael S.","family":"Stringer","sequence":"additional","affiliation":[{"name":"Brain Research Imaging Centre, Centre for Clinical Brain Sciences UK Dementia Research Institute Centre at the University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Hendrikse","sequence":"additional","affiliation":[{"name":"Department of Radiology, Center for Image Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-6642","authenticated-orcid":false,"given":"Joanna M.","family":"Wardlaw","sequence":"additional","affiliation":[{"name":"Brain Research Imaging Centre, Centre for Clinical Brain Sciences UK Dementia Research Institute Centre at the University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3963-3860","authenticated-orcid":false,"given":"Anne","family":"Joutel","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry and Neurosciences of Paris, Universit\u00e9 de Paris  Inserm U1266 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Dichgans","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research University Hospital, Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"},{"name":"German Center for Neurodegenerative Disease (DZNE)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert Jan","family":"Biessels","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the SVDs@target group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30079-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.3122"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.04.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.02.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24758"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2017.02565"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70127-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0778-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988710383570"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39733"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1420765112"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14678"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016996"},{"key":"e_1_2_8_16_1","article-title":"Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: rationale and design of the \u201cZOOM@SVDs\u201d study","volume":"2","author":"Brink H","year":"2021","journal-title":"Cereb Circ\u2014Cogn Behav"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24967"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3306"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022516"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27304"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.030"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.05.051"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.91008.2008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.643468"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017730740"},{"key":"e_1_2_8_27_1","first-page":"1","article-title":"Reduced blood flow velocity in lenticulostriate arteries of patients with CADASIL assessed by PC\u2010MRA at 7T","volume":"0","author":"Sun C","year":"2021","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000236838.84150.c2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12177"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27989"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0844-x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003717"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.8.1904"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4064"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.02.004"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.02.063"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034866"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpet.2013.04.003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26821"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.26527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ana.26527","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.26527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T21:14:49Z","timestamp":1702415689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.26527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/ana.26527"],"URL":"https:\/\/doi.org\/10.1002\/ana.26527","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}