{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:50:03Z","timestamp":1792403403518,"version":"4.4.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000114"],"award-info":[{"award-number":["UL1TR000114"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41 EB027061"],"award-info":[{"award-number":["P41 EB027061"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P30 NS076408"],"award-info":[{"award-number":["P30 NS076408"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01 NS104326"],"award-info":[{"award-number":["U01 NS104326"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR\u20101644779"],"award-info":[{"award-number":["DMR\u20101644779"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10 OD017974"],"award-info":[{"award-number":["S10 OD017974"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10 OD021726"],"award-info":[{"award-number":["S10 OD021726"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007698","name":"University of Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012892","name":"National High Magnetic Field Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was undertaken to identify magnetic resonance (MR) metrics that are most sensitive to early changes in the brain in spinocerebellar ataxia type 1 (SCA1) and type 3 (SCA3) using an advanced multimodal MR imaging (MRI) protocol in the multisite trial setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SCA1 or SCA3 mutation carriers and controls (n\u00a0=\u00a0107) underwent MR scanning in the US\u2010European READISCA study to obtain structural, diffusion MRI, and MR spectroscopy data using an advanced protocol at 3T. Morphometric, microstructural, and neurochemical metrics were analyzed blinded to diagnosis and compared between preataxic SCA (n\u00a0=\u00a011 SCA1, n\u00a0=\u00a028 SCA3), ataxic SCA (n\u00a0=\u00a014 SCA1, n\u00a0=\u00a037 SCA3), and control (n\u00a0=\u00a017) groups using nonparametric testing accounting for multiple comparisons. MR metrics that were most sensitive to preataxic abnormalities were identified using receiver operating characteristic (ROC) analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Atrophy and microstructural damage in the brainstem and cerebellar peduncles and neurochemical abnormalities in the pons were prominent in both preataxic groups, when patients did not differ from controls clinically. MR metrics were strongly associated with ataxia symptoms, activities of daily living, and estimated ataxia duration. A neurochemical measure was the most sensitive metric to preataxic changes in SCA1 (ROC area under the curve [AUC]\u00a0=\u00a00.95), and a microstructural metric was the most sensitive metric to preataxic changes in SCA3 (AUC\u00a0=\u00a00.92).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Changes in cerebellar afferent and efferent pathways underlie the earliest symptoms of both SCAs. MR metrics collected with a harmonized advanced protocol in the multisite trial setting allow detection of disease effects in individuals before ataxia onset with potential clinical trial utility for subject stratification. ANN NEUROL 2023;93:686\u2013701<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.26573","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T07:55:22Z","timestamp":1670918122000},"page":"686-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Clinically Meaningful\n                    <scp>Magnetic Resonance<\/scp>\n                    Endpoints Sensitive to Preataxic Spinocerebellar Ataxia Types\n                    <scp>1<\/scp>\n                    and\n                    <scp>3<\/scp>"],"prefix":"10.1002","volume":"93","author":[{"given":"Jayashree","family":"Chandrasekaran","sequence":"first","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilien","family":"Petit","sequence":"additional","affiliation":[{"name":"Paris Brain Institute Sorbonne University, National Institute of Health and Medical Research (Inserm), National Institute for Research in Digital Science and Technology (INRIA), National Center for Scientific Research (CNRS), Assistance Publique \u2010 H\u00f4pitaux de Paris (APHP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie Tezenas","family":"du Montcel","sequence":"additional","affiliation":[{"name":"Paris Brain Institute Sorbonne University, National Institute of Health and Medical Research (Inserm), National Institute for Research in Digital Science and Technology (INRIA), National Center for Scientific Research (CNRS), Assistance Publique \u2010 H\u00f4pitaux de Paris (APHP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Joers","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh K.","family":"Deelchand","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Pova\u017ean","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guita","family":"Banan","sequence":"additional","affiliation":[{"name":"Norman Fixel Center for Neurological Disorders, College of Medicine University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Valabregue","sequence":"additional","affiliation":[{"name":"Paris Brain Institute Sorbonne University, National Institute of Health and Medical Research (Inserm), National Institute for Research in Digital Science and Technology (INRIA), National Center for Scientific Research (CNRS), Assistance Publique \u2010 H\u00f4pitaux de Paris (APHP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Ehses","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Faber","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Bonn Germany"},{"name":"Department of Neurology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Coup\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoire Bordelais de Recherche en Informatique (LaBRI) Bordeaux University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiadi U.","family":"Onyike","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Schmahmann","sequence":"additional","affiliation":[{"name":"Ataxia Center, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology Massachusetts General Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva\u2010Maria","family":"Ratai","sequence":"additional","affiliation":[{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital  Charlestown MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8052-9240","authenticated-orcid":false,"given":"S. H.","family":"Subramony","sequence":"additional","affiliation":[{"name":"Norman Fixel Center for Neurological Disorders, College of Medicine University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Mareci","sequence":"additional","affiliation":[{"name":"Norman Fixel Center for Neurological Disorders, College of Medicine University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalaf O.","family":"Bushara","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Paulson","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Durr","sequence":"additional","affiliation":[{"name":"Paris Brain Institute Sorbonne University, National Institute of Health and Medical Research (Inserm), National Institute for Research in Digital Science and Technology (INRIA), National Center for Scientific Research (CNRS), Assistance Publique \u2010 H\u00f4pitaux de Paris (APHP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klockgether","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Bonn Germany"},{"name":"Department of Neurology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Ashizawa","sequence":"additional","affiliation":[{"name":"Stanley H. Appel Department of Neurology Houston Methodist Research Institute  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Lenglet","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5769-183X","authenticated-orcid":false,"given":"G\u00fclin","family":"\u00d6z","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the READISCA Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-177"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822e7ca0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00737-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0051-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201600048"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000834"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25297"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28610"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70104-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-010-0214-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00411"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25212"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12804"},{"key":"e_1_2_8_15_1","unstructured":"Clinical Trial Readiness for SCA1 and SCA3 (READISCA) NCT03487367. Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03487367."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001711"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219042.60538.92"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-102200"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012068"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn059"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-012-0421-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx317"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000218155.46739.90"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27203"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4218"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27742"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25295"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29164"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10278-012-9462-x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-012-9160-3"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00558"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.064"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236418"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25295"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.016"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.065"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.11.003"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-020-01227-2"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/s22041345"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2013.03.004"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300604"},{"key":"e_1_2_8_45_1","unstructured":"Biogen. A Pharmacokinetics and Safety Study of BIIB132 in Adults With Spinocerebellar Ataxia 3 NCT05160558. 2021. Available from:https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05160558."},{"key":"e_1_2_8_46_1","first-page":"153","article-title":"Dopamine transporter concentration is reduced in asymptomatic Machado\u2010Joseph disease gene carriers","volume":"43","author":"Yen TC","year":"2002","journal-title":"J Nucl Med"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.4.499"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.07.027"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws369"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-021-01285-0"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28113"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1267"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00092"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21965"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx224"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1954-20.2021"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-014-0627-7"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282x20180080"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.10.016"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5612-09.2010"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12435"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29032"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.26573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ana.26573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.26573","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.26573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T07:37:27Z","timestamp":1705477047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.26573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/ana.26573"],"URL":"https:\/\/doi.org\/10.1002\/ana.26573","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]},"assertion":[{"value":"2022-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}