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However, evidence from cerebrospinal fluid (CSF) is lacking. Here, we evaluated individual amine levels, global amine profiles, and amine pathways in CSF and plasma of interictal migraine patients and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CSF and plasma were sampled between 8:30 <jats:sc>am<\/jats:sc> and 1:00 <jats:sc>pm<\/jats:sc>, randomly and interchangeably over the time span to avoid any diurnal and seasonal influences, from healthy volunteers and interictal migraine patients, matched for age, sex, and sampling time. The study was approved by the local medical ethics committee. Individual amines (n\u00a0=\u00a031), global amine profiles, and specific amine pathways were analyzed using a validated ultraperformance liquid chromatography mass spectrometry platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed n\u00a0=\u00a099 participants with migraine with aura, n\u00a0=\u00a098 with migraine without aura, and n\u00a0=\u00a096 healthy volunteers. Univariate analysis with Bonferroni correction indicated that CSF L\u2010arginine was reduced in migraine with aura (10.4%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) and without aura (5.0%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.03). False discovery rate\u2010corrected CSF L\u2010phenylalanine was also lower in migraine with aura (6.9%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.011) and without aura (8.1%, <jats:italic>p<\/jats:italic>\u00a0=\u20090.001), <jats:italic>p<\/jats:italic>\u00a0=\u20090.088 after Bonferroni correction. Multivariate analysis revealed that CSF global amine profiles were similar for both types of migraine (<jats:italic>p<\/jats:italic>\u00a0=\u20090.64), but distinct from controls (<jats:italic>p<\/jats:italic>\u00a0=\u20090.009). Global profile analyses were similar in plasma. The strongest associated pathways with migraine were related to L\u2010arginine metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>L\u2010Arginine was decreased in the CSF (but not in plasma) of interictal patients with migraine with or without aura, and associated pathways were altered. This suggests that dysfunction of nitric oxide signaling is involved in susceptibility to getting migraine attacks. ANN NEUROL 2023;93:715\u2013728<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.26576","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T14:57:06Z","timestamp":1670943426000},"page":"715-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cerebrospinal Fluid and Plasma Amine Profiles in Interictal Migraine"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0958-4754","authenticated-orcid":false,"given":"Gerrit L. 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