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We investigated longitudinal changes of partial volume corrected <jats:sup>11<\/jats:sup>C\u2010UCB\u2010J standardized uptake value ratio (SUVR; relative to centrum semiovale) within the ischemic lesion, peri\u2010ischemic area and unaffected ipsilesional and contralesional grey matter. We also explored crossed cerebellar diaschisis at 6\u2009months. Additionally, we defined brain regions potentially influencing upper limb motor recovery after stroke and studied <jats:sup>11<\/jats:sup>C\u2010UCB\u2010J SUVR evolution in comparison to baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 13 patients (age\u00a0=\u00a067\u2009\u00b1\u200915\u2009years) we observed decreasing <jats:sup>11<\/jats:sup>C\u2010UCB\u2010J SUVR in the ischemic lesion (\u0394SUVR\u00a0=\u00a0\u22121.0, <jats:italic>p<\/jats:italic>\u00a0=\u20090.001) and peri\u2010ischemic area (\u0394SUVR\u00a0=\u00a0\u22120.31, <jats:italic>p<\/jats:italic>\u00a0=\u20090.02) at 6\u2009months after stroke compared to baseline. Crossed cerebellar diaschisis as measured with <jats:sup>11<\/jats:sup>C\u2010UCB\u2010J SUVR was present in 11 of 13 (85%) patients at 6\u2009months. The <jats:sup>11<\/jats:sup>C\u2010UCB\u2010J SUVR did not augment in ipsilesional or contralesional brain regions associated with motor recovery. On the contrary, there was an overall trend of declining <jats:sup>11<\/jats:sup>C\u2010UCB\u2010J SUVR in these brain regions, reaching statistical significance only in the nonlesioned part of the ipsilesional supplementary motor area (\u0394SUVR\u00a0=\u00a0\u22120.83, <jats:italic>p<\/jats:italic>\u00a0=\u20090.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>At 6\u2009months after stroke, synaptic density further declined in the ischemic lesion and peri\u2010ischemic area compared to baseline. Brain regions previously demonstrated to be associated with motor recovery after stroke did not show increases in synaptic density. 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