{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:38:52Z","timestamp":1793025532629,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI18C1159"],"award-info":[{"award-number":["HI18C1159"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HU20C0164"],"award-info":[{"award-number":["HU20C0164"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6\u20102021\u20100094"],"award-info":[{"award-number":["6\u20102021\u20100094"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Although growing evidence suggests that perivascular space (PVS) serves as a clearance route for amyloid and tau, the association between enlarged PVS (EPVS) and Alzheimer disease is highly inconsistent across studies. As the conventional visual rating systems for EPVS were insufficient to predict amyloid\/tau\/neurodegeneration (A\/T\/N) status, we developed a new rating scale for EPVS located in the temporal lobe (T\u2010EPVS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EPVS located in the basal ganglia (BG\u2010EPVS), centrum semiovale (CS\u2010EPVS), and T\u2010EPVS was visually rated in 272 individuals (healthy controls, n\u00a0=\u00a096; mild cognitive impairment, n\u00a0=\u00a0106; dementia, n\u00a0=\u00a070) who underwent structural magnetic resonance imaging (MRI) and dual positron emission tomography scans (<jats:sup>18<\/jats:sup>F\u2010flortaucipir and <jats:sup>18<\/jats:sup>F\u2010florbetaben). T\u2010EPVS and BG\u2010EPVS were defined as high degree when the counts in any hemisphere were\u2009&gt;10, and the CS\u2010EPVS cutoff was &gt;20. Logistic regression models were constructed to investigate whether the regional EPVS burden was predictive of A\/T\/N status. The derived models were externally validated in a temporal validation cohort (n\u00a0=\u00a0195) that underwent MRI studies using a different scanner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with those with low\u2010degree T\u2010EPVS (23\/136, 16.9%), individuals with high\u2010degree T\u2010EPVS\/CS\u2010EPVS but low\u2010degree BG\u2010EPVS were more likely to exhibit amyloid positivity (46\/56, 82.1%). High\u2010degree T\u2010EPVS burden (odds ratio [OR]\u00a0=\u00a07.251, 95% confidence interval [CI]\u00a0=\u00a03.296\u201315.952) and low\u2010degree BG\u2010EPVS (OR\u00a0=\u00a00.241, 95% CI\u00a0=\u00a00.109\u20130.530) were predictive of amyloid positivity. Although high\u2010degree T\u2010EPVS was associated with tau positivity, the association was no longer significant after adjusting for amyloid and neurodegeneration status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Investigating the burden and topographic distribution of EPVS including T\u2010EPVS may be useful for predicting amyloid status, indicating that impaired perivascular drainage may contribute to cerebral amyloidosis. ANN NEUROL 2023;93:965\u2013978<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.26601","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T12:10:13Z","timestamp":1674043813000},"page":"965-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Role of Enlarged Perivascular Space in the Temporal Lobe in Cerebral Amyloidosis"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-1641","authenticated-orcid":false,"given":"Han Kyu","family":"Na","sequence":"first","affiliation":[{"name":"Department of Neurology, Gangnam Severance Hospital Yonsei University College of Medicine  Seoul South Korea"},{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South 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