{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:47:25Z","timestamp":1791586045064,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014808","name":"Fondation Vaincre Alzheimer","doi-asserted-by":"publisher","award":["13732"],"award-info":[{"award-number":["13732"]}],"id":[{"id":"10.13039\/100014808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["667696"],"award-info":[{"award-number":["667696"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018696","name":"R\u00e9gion Normandie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018696","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Rapid eye movement (REM) sleep is markedly altered in Alzheimer's disease (AD), and its reduction in older populations is associated with AD risk. However, little is known about the underlying brain mechanisms. Our objective was to investigate the relationships between REM sleep integrity and amyloid deposition, gray matter volume, and perfusion in aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 121 cognitively unimpaired older adults (76 women, mean age 68.96\u2009\u00b1\u20093.82\u2009years), who underwent a polysomnography, T1\u2010weighted magnetic resonance imaging, early and late Florbetapir positron emission tomography scans to evaluate gray matter volume, perfusion, and amyloid deposition. We computed indices reflecting REM sleep macro\u2010 and microstructural integrity (ie, normalized electroencephalographic spectral power values). Voxel\u2010wise multiple regression analyses were conducted between REM sleep indices and neuroimaging data, controlling for age, sex, education, the apnea\u2010hypopnea index, and the apolipoprotein\u2009E \u03b54 status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lower perfusion in frontal, anterior and posterior cingulate, and precuneus areas was associated with decreased delta power and electroencephalographic slowing (slow\/fast frequencies ratio), and increased alpha and beta power. To a lower extent, similar results were obtained between gray matter volume and delta, alpha, and beta power. In addition, lower REM sleep theta power was more marginally associated with greater diffuse amyloid deposition and lower gray matter volume in fronto\u2010temporal and parieto\u2010occipital areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>These results suggest that alterations of REM sleep microstructure are associated with greater neurodegeneration and neocortical amyloid deposition in older adults. Further studies are warranted to replicate these findings, and determine whether older adults exhibiting REM sleep alterations are more at risk of cognitive decline and belonging to the Alzheimer's continuum. ANN NEUROL 2023;93:979\u2013990<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.26604","type":"journal-article","created":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T03:54:20Z","timestamp":1673754860000},"page":"979-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Rapid Eye Movement Sleep, Neurodegeneration, and Amyloid Deposition in Aging"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-1108","authenticated-orcid":false,"given":"Claire","family":"Andr\u00e9","sequence":"first","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"},{"name":"Normandie Univ, UNICAEN PSL Universit\u00e9, EPHE, INSERM, U1077, Caen University Hospital, GIP Cyceron, NIMH Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0228-6084","authenticated-orcid":false,"given":"Pierre","family":"Champetier","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"},{"name":"Normandie Univ, UNICAEN PSL Universit\u00e9, EPHE, INSERM, U1077, Caen University Hospital, GIP Cyceron, NIMH Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Rehel","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"},{"name":"Normandie Univ, UNICAEN PSL Universit\u00e9, EPHE, INSERM, U1077, Caen University Hospital, GIP Cyceron, NIMH Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edelweiss","family":"Touron","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Ourry","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"},{"name":"Normandie Univ, UNICAEN PSL Universit\u00e9, EPHE, INSERM, U1077, Caen University Hospital, GIP Cyceron, NIMH Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Landeau","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendoline","family":"Le Du","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"M\u00e9zenge","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-8210","authenticated-orcid":false,"given":"Shailendra","family":"Segobin","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN PSL Universit\u00e9, EPHE, INSERM, U1077, Caen University Hospital, GIP Cyceron, NIMH Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"de la Sayette","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN PSL Universit\u00e9, EPHE, INSERM, U1077, Caen University Hospital, GIP Cyceron, NIMH Caen France"},{"name":"Neurology Department Caen University Hospital Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Vivien","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"},{"name":"Clinical Research Department Caen University Hospital Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4889-7932","authenticated-orcid":false,"given":"Ga\u00ebl","family":"Ch\u00e9telat","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-2189","authenticated-orcid":false,"given":"G\u00e9raldine","family":"Rauchs","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNICAEN, INSERM, U1237 PhIND \"Physiopathology and Imaging of Neurological Disorders\", NeuroPresage Team, GIP Cyceron Caen France"},{"name":"Normandie Univ, UNICAEN PSL Universit\u00e9, EPHE, INSERM, U1077, Caen University Hospital, GIP Cyceron, NIMH Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Medit\u2010Ageing Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2000.0136"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.01.017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2004.02.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000117446"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.03.007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2015.04.027"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.01.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101308"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12821"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720512800107609"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1550059415603050"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4500"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004373"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.01662"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.11.011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.12.012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.10.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6576"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.11.1587"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.13424","article-title":"Variability of sleep stage scoring in late midlife and early old age","volume":"31","author":"Chylinski D","year":"2021","journal-title":"J Sleep Res"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00197"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.188"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0311"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4035"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.08.017"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.6240"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12184"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.0049"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy184"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(93)90089-T"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.2510"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.06.2362"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.06.3916"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.06.019"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13249"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00586-X"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.2.199"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10069"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2003-5106"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S135561771200001X"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00985"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00542-3"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2801"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(92)90008-9"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.26604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ana.26604","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.26604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T14:25:22Z","timestamp":1701699922000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.26604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/ana.26604"],"URL":"https:\/\/doi.org\/10.1002\/ana.26604","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]},"assertion":[{"value":"2021-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}