{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:30:00Z","timestamp":1793244600654,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01NS104147\u201002"],"award-info":[{"award-number":["5R01NS104147\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010573","name":"Stichting Dioraphte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["733050822"],"award-info":[{"award-number":["733050822"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Vascular amyloid \u03b2 (A\u03b2) accumulation is the hallmark of cerebral amyloid angiopathy (CAA). The composition of cerebrospinal fluid (CSF) of CAA patients may serve as a diagnostic biomarker of CAA. We studied the diagnostic potential of the peptides A\u03b238, A\u03b240, A\u03b242, and A\u03b243 in patients with sporadic CAA (sCAA), hereditary Dutch\u2010type CAA (D\u2010CAA), and Alzheimer disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A\u03b2 peptides were quantified by immunoassays in a discovery group (26 patients with sCAA and 40 controls), a validation group (40 patients with sCAA, 40 patients with AD, and 37 controls), and a group of 22 patients with D\u2010CAA and 54 controls. To determine the diagnostic accuracy, the area under the curve (AUC) was calculated using a receiver operating characteristic curve with 95% confidence interval (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found decreased levels of all A\u03b2 peptides in sCAA patients and D\u2010CAA patients compared to controls. The difference was most prominent for A\u03b242 (AUC of sCAA vs controls for discovery: 0.90, 95% CI\u00a0=\u00a00.82\u20130.99; for validation: 0.94, 95% CI\u00a0=\u00a00.89\u20130.99) and A\u03b243 (AUC of sCAA vs controls for discovery: 0.95, 95% CI\u00a0=\u00a00.88\u20131.00; for validation: 0.91, 95% CI\u00a0=\u00a00.83\u20131.0). All A\u03b2 peptides except A\u03b243 were also decreased in sCAA compared to AD (CSF A\u03b238: AUC\u00a0=\u00a00.82, 95% CI\u00a0=\u00a00.71\u20130.93; CSF A\u03b240: AUC\u00a0=\u00a00.88, 95% CI\u00a0=\u00a00.80\u20130.96; CSF A\u03b242: AUC\u00a0=\u00a00.79, 95% CI\u00a0=\u00a00.66\u20130.92).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>A combined biomarker panel of CSF A\u03b238, A\u03b240, A\u03b242, and A\u03b243 has potential to differentiate sCAA from AD and controls, and D\u2010CAA from controls. ANN NEUROL 2023;93:1173\u20131186<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.26610","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T23:35:39Z","timestamp":1674862539000},"page":"1173-1186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Decreased Cerebrospinal Fluid Amyloid \u03b2 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid Angiopathy"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5679-516X","authenticated-orcid":false,"given":"Anna M.","family":"De Kort","sequence":"first","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-7428","authenticated-orcid":false,"given":"H. Bea","family":"Kuiperij","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-2817","authenticated-orcid":false,"given":"Tain\u00e1 M.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9378-3256","authenticated-orcid":false,"given":"Lieke","family":"J\u00e4kel","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9004-934X","authenticated-orcid":false,"given":"Emma","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kersten","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behavior  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo E. 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