{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:40:58Z","timestamp":1791423658415,"version":"4.3.3"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"\n Objective<\/jats:title>\n To characterize neurologic manifestations in post\u2010hospitalization Neuro\u2010PASC (PNP) and non\u2010hospitalized Neuro\u2010PASC (NNP) patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Prospective study of the first 100 consecutive PNP and 500 NNP patients evaluated at a Neuro\u2010COVID\u201019 clinic between 5\/2020 and 8\/2021.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n PNP were older than NNP patients (mean 53.9 vs 44.9 y;\n p<\/jats:italic>\n \u2009<\u20090.0001) with a higher prevalence of pre\u2010existing comorbidities. An average 6.8\u2009months from onset, the main neurologic symptoms were \u201cbrain fog\u201d (81.2%), headache (70.3%), and dizziness (49.5%) with only anosmia, dysgeusia and myalgias being more frequent in the NNP compared to the PNP group (59 vs 39%, 57.6 vs 39% and 50.4 vs 33%, all\n p<\/jats:italic>\n \u2009<\u20090.003). Moreover, 85.8% of patients experienced fatigue. PNP more frequently had an abnormal neurologic exam than NNP patients (62.2 vs 37%,\n p<\/jats:italic>\n \u2009<\u20090.0001). Both groups had impaired quality of life in cognitive, fatigue, sleep, anxiety, and depression domains. PNP patients performed worse on processing speed, attention, and working memory tasks than NNP patients (T\u2010score 41.5 vs 55, 42.5 vs 47 and 45.5 vs 49, all\n p<\/jats:italic>\n \u2009<\u20090.001) and a US normative population. NNP patients had lower results in attention task only. Subjective impression of cognitive ability correlated with cognitive test results in NNP but not in PNP patients.\n <\/jats:p>\n <\/jats:sec>\n \n Interpretation<\/jats:title>\n PNP and NNP patients both experience persistent neurologic symptoms affecting their quality of life. However, they harbor significant differences in demographics, comorbidities, neurologic symptoms and findings, as well as pattern of cognitive dysfunction. Such differences suggest distinct etiologies of Neuro\u2010PASC in these populations warranting targeted interventions. ANN NEUROL 2023;94:146\u2013159<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ana.26649","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T12:15:43Z","timestamp":1679832943000},"page":"146-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Neurologic Manifestations of Long\n COVID<\/scp>\n Differ Based on Acute\n COVID<\/scp>\n \u201019 Severity"],"prefix":"10.1002","volume":"94","author":[{"given":"Gina S.","family":"Perez Giraldo","sequence":"first","affiliation":[{"name":"Davee Department of Neurology Northwestern University Feinberg School of Medicine Chicago IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-3782","authenticated-orcid":false,"given":"Sareen T.","family":"Ali","sequence":"additional","affiliation":[{"name":"Davee Department of Neurology Northwestern University Feinberg School of Medicine Chicago 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