{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:26:47Z","timestamp":1787700407336,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","award":["I5Q\u2010NS\u2010O002"],"award-info":[{"award-number":["I5Q\u2010NS\u2010O002"]}],"id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018812","name":"Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla","doi-asserted-by":"publisher","award":["INNVAL 20\/25"],"award-info":[{"award-number":["INNVAL 20\/25"]}],"id":[{"id":"10.13039\/501100018812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["Pi20\/01358"],"award-info":[{"award-number":["Pi20\/01358"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to analyze the evolution of alpha and beta\u2010CGRP circulating levels throughout CGRP monoclonal antibodies (mAbs) treatment in patients with chronic migraine (CM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited patients with CM beginning mAbs along with sex and age paired healthy controls (HCs). Blood was extracted before, 2\u2009weeks (M0.5) and 3\u2009months (M3) after the first dose of mAbs, always in free\u2010migraine periods, and once for HCs. Alpha and beta\u2010CGRP serum levels were measured using enzyme\u2010linked immunosorbent assays (ELISAs) specific for each isoform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline alpha\u2010CGRP levels were significantly elevated in 103 patients with CM (median\u2009=\u200950.3, 95% confidence interval [CI]\u2009=\u200940.5\u201357.0 pg\/ml) compared to 78 HCs (median\u2009=\u200937.5, 95% CI\u2009=\u200933.9\u201345.0 pg\/ml; 95% CI of differences\u2009=\u20092.85\u201317.08\u2009pg\/ml) and significantly decreased (n\u2009=\u200996) over the course of mAb treatment (M0.5: median\u2009=\u200940.4, 95% CI\u2009=\u200935.6\u201348.2 pg\/ml; and M3: median\u2009=\u200940.9, 95% CI\u2009=\u200936.3\u201345.9 pg\/ml). Absolute decrease of alpha\u2010CGRP throughout the treatment positively correlated with the decrease in MMDs. Negative modulation of alpha\u2010CGRP significantly associated with positive scores at the Patient Global Impression of Change scale and with analgesic overuse reversal. Beta\u2010CGRP did not differ at baseline between patients with CM (median\u2009=\u20094.2, 95% CI\u2009=\u20093.0\u20134.8 pg\/ml) and HCs (median\u2009=\u20094.4, 95% CI\u2009=\u20093.4\u20135.6 pg\/ml; \u22121.09 to 0.60) nor was modulated by mAb treatment (n\u2009=\u200996; M0.5: median\u2009=\u20094.5, 95% CI\u2009=\u20093.5\u20135.2 pg\/ml; and M3: median\u2009=\u20094.6, 95% CI\u2009=\u20093.7\u20135.2 pg\/ml).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Treatment with mAbs, regardless of its target, is able to progressively normalize basally increased alpha\u2010CGRP levels in CM and this effect correlates with efficacy measures, which supports a role of this neuropeptide as the first CM biomarker. ANN NEUROL 2023;94:285\u2013294<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.26658","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T07:20:26Z","timestamp":1681197626000},"page":"285-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Serum Alpha and <scp>Beta\u2010CGRP<\/scp> Levels in Chronic Migraine Patients Before and After Monoclonal Antibodies Against <scp>CGRP<\/scp> or its Receptor"],"prefix":"10.1002","volume":"94","author":[{"given":"Gabriel","family":"G\u00e1rate","sequence":"first","affiliation":[{"name":"Service of Neurology of the University Hospital Marqu\u00e9s de Valdecilla  Santander Spain"},{"name":"Instituto de Investigaci\u00f3n Valdecilla, IDIVAL  Santander Spain"},{"name":"Universidad de Cantabria  Santander 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