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The spatial correlation between regional glymphatic function and bvFTD remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A total of 74 patients with bvFTD and 67 age\u2010 and sex\u2010matched healthy controls (HCs) were selected from discovery dataset and replication dataset. All participants underwent neuropsychological assessment. Glymphatic measures including choroid plexus (CP) volume, diffusion tensor imaging along the perivascular (DTI\u2010ALPS) index, and coupling between blood\u2010oxygen\u2010level\u2010dependent signals and cerebrospinal fluid signals (BOLD\u2010CSF coupling), were compared between the two groups. Regional glymphatic function was evaluated by dividing DTI\u2010ALPS and BOLD\u2010CSF coupling into anterior, middle, and posterior regions. The bvFTD\u2010related metabolic pattern was identified using spatial covariance analysis based on\n                      <jats:sup>l8<\/jats:sup>\n                      F\u2010FDG\u2010PET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with bvFTD showed higher CP volume (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); anterior and middle DTI\u2010ALPS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); and weaker anterior BOLD\u2010CSF coupling (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) than HCs after controlling for cortical gray matter volume in both datasets. In bvFTD from the discovery dataset, the anterior DTI\u2010ALPS was negatively associated with the expression of the bvFTD\u2010related metabolic pattern (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034) and positively related with regional standardized uptake value ratios of\n                      <jats:sup>l8<\/jats:sup>\n                      F\u2010FDG\u2010PET in bvFTD\u2010related brain regions (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009range:\u20090.49 to 0.62,\n                      <jats:italic>p<\/jats:italic>\n                      range: 0.017 to 0.047). Anterior and middle glymphatic functions were related to global cognition and disease severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Our findings reveal abnormal glymphatic function, especially in the anterior and middle regions of brain in bvFTD. Regional glymphatic dysfunction may contribute to the pathogenesis of bvFTD. ANN NEUROL 2023;94:442\u2013456<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.26710","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T01:18:26Z","timestamp":1685150306000},"page":"442-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":137,"title":["Regional Glymphatic Abnormality in Behavioral Variant Frontotemporal Dementia"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-0293","authenticated-orcid":false,"given":"Deming","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing 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