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LATE affects approximately one\u2010quarter of older adults and produces an amnestic syndrome that is commonly mistaken for Alzheimer's disease (AD). Although AD and LATE often co\u2010occur in the same patients, these diseases differ in the protein aggregates driving neuropathology (A\u03b2 amyloid\/tau vs TDP\u201043). This review discusses signs and symptoms, relevant diagnostic testing, and potential treatment implications for LATE that may be helpful for physicians, patients, and families. 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