{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:51:19Z","timestamp":1789440679842,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Epidemiological data to characterize the individual risk profile of patients with spontaneous cervical artery dissection (sCeAD) are rather inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>In the setting of the Italian Project on Stroke in Young Adults Cervical Artery Dissection (IPSYS CeAD), we compared the characteristics of 1,468 patients with sCeAD (mean age\u2009=\u200947.3\u2009\u00b1\u200911.3\u2009years, men\u2009=\u200956.7%) prospectively recruited at 39 Italian centers with those of 2 control groups, composed of (1) patients whose ischemic stroke was caused by mechanisms other than dissection (non\u2010CeAD IS) selected from the prospective IPSYS registry and Brescia Stroke Registry and (2) stroke\u2010free individuals selected from the staff members of participating hospitals, matched 1:1:1 by sex, age, and race. Compared to stroke\u2010free subjects, patients with sCeAD were more likely to be hypertensive (odds ratio [OR]\u2009=\u20091.65, 95% confidence interval [CI]\u2009=\u20091.37\u20131.98), to have personal history of migraine with aura (OR\u2009=\u20092.45, 95% CI\u2009=\u20091.74\u20133.34), without aura (OR\u2009=\u20092.67, 95% CI\u2009=\u20092.15\u20133.32), and family history of vascular disease in first\u2010degree relatives (OR\u2009=\u20091.69, 95% CI\u2009=\u20091.39\u20132.05), and less likely to be diabetic (OR\u2009=\u20090.65, 95% CI\u2009=\u20090.47\u20130.91), hypercholesterolemic (OR\u2009=\u20090.75, 95% CI\u2009=\u20090.62\u20130.91), and obese (OR\u2009=\u20090.41, 95% CI\u2009=\u20090.31\u20130.54). Migraine without aura was also associated with sCeAD (OR\u2009=\u20091.81, 95% CI\u2009=\u20091.47\u20132.22) in comparison with patients with non\u2010CeAD IS. In the subgroup of patients with migraine, patients with sCeAD had higher frequency of migraine attacks and were less likely to take anti\u2010migraine preventive medications, especially beta\u2010blockers, compared with the other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The risk of sCeAD is influenced by migraine, especially migraine without aura, more than by other factors, increases with increasing frequency of attacks, and seems to be reduced by migraine preventive medications, namely beta\u2010blockers. ANN NEUROL 2023;94:585\u2013595<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.26717","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T18:32:54Z","timestamp":1686162774000},"page":"585-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Risk Profile of Patients with Spontaneous Cervical Artery Dissection"],"prefix":"10.1002","volume":"94","author":[{"given":"Elisabetta","family":"Del Zotto","sequence":"first","affiliation":[{"name":"U.O. Neurologia Dipartimento Testa\u2010Collo, Istituto Ospedaliero Poliambulanza  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Grassi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Unit\u00e0 di Statistica Medica e Genomica Universit\u00e0 di Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Zedde","sequence":"additional","affiliation":[{"name":"S.C. 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Malattie Cerebrovascolari, Fondazione IRCCS Istituto Neurologico \u201cCarlo Besta\u201d  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Gandolfo","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno\u2010Infantili Universit\u00e0 di Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Silvestrelli","sequence":"additional","affiliation":[{"name":"Stroke Unit, Dipartimento di Neuroscienze, Ospedale Carlo Poma  Mantova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Baracchini","sequence":"additional","affiliation":[{"name":"U.O.S.D. 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