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The autoantigen was identified by immunoprecipitation and mass spectrometry and confirmed by antigen\u2010specific assays to be specific for tenascin\u2010R. He was investigated for cancer and diagnosed with follicular lymphoma that expressed tenascin\u2010R suggesting a paraneoplastic origin; cancer treatment and immunotherapy led to complete recovery. With this individualized patient approach and antibody discovery, we expand the spectrum of antibodies accompanying autoimmune hyperkinetic movement disorders. 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