{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:26:02Z","timestamp":1786976762348,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to characterize a metabolic brain network associated with X\u2010linked dystonia\u2010parkinsonism (XDP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty right\u2010handed Filipino men with XDP (age\u2009=\u200944.4\u2009\u00b1\u20098.5\u2009years) and 30 XDP\u2010causing mutation negative healthy men from the same population (age\u2009=\u200937.4\u2009\u00b1\u200910.5\u2009years) underwent [\n                      <jats:sup>18<\/jats:sup>\n                      F]\u2010fluorodeoxyglucose positron emission tomography. Scans were analyzed using spatial covariance mapping to identify a significant XDP\u2010related metabolic pattern (XDPRP). Patients were rated clinically at the time of imaging according to the XDP\u2010Movement Disorder Society of the Philippines (MDSP) scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified a significant XDPRP topography from 15 randomly selected subjects with XDP and 15 control subjects. This pattern was characterized by bilateral metabolic reductions in caudate\/putamen, frontal operculum, and cingulate cortex, with relative increases in the bilateral somatosensory cortex and cerebellar vermis. Age\u2010corrected expression of XDPRP was significantly elevated (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) in XDP compared to controls in the derivation set and in the remaining 15 patients (testing set). We validated the XDPRP topography by identifying a similar pattern in the original testing set (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001; voxel\u2010wise correlation between both patterns). Significant correlations between XDPRP expression and clinical ratings for parkinsonism\u2014but not dystonia\u2014were observed in both XDP groups. Further network analysis revealed abnormalities of information transfer through the XDPRP space, with loss of normal connectivity and gain of abnormal functional connections linking network nodes with outside brain regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>XDP is associated with a characteristic metabolic network associated with abnormal functional connectivity among the basal ganglia, thalamus, motor regions, and cerebellum. Clinical signs may relate to faulty information transfer through the network to outside brain regions. ANN NEUROL 2023;94:684\u2013695<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.26732","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T01:49:16Z","timestamp":1687916956000},"page":"684-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Network Imaging Biomarker of X\u2010Linked Dystonia\u2010Parkinsonism"],"prefix":"10.1002","volume":"94","author":[{"given":"Martin","family":"Niethammer","sequence":"first","affiliation":[{"name":"Center for Neurosciences The Feinstein Institutes for Medical Research  Manhasset New York"},{"name":"Department of Neurology Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell  Hempstead New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris C.","family":"Tang","sequence":"additional","affiliation":[{"name":"Center for Neurosciences The Feinstein Institutes for Medical Research  Manhasset 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