{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:19:56Z","timestamp":1792264796229,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Computed tomography perfusion (CTP) has played an important role in patient selection for mechanical thrombectomy (MT) in acute ischemic stroke. We aimed to investigate the agreement between perfusion parametric maps of 3 software packages \u2013 RAPID (RapidAI\u2010IschemaView), Viz CTP(Viz.ai), and e\u2010CTP(Brainomix) \u2013 in estimating baseline ischemic core volumes of near completely\/completely reperfused patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed a prospectively maintained MT database to identify patients with anterior circulation large vessel occlusion strokes (LVOS) involving the internal carotid artery or middle cerebral artery M1\u2010segment and interpretable CTP maps treated during September 2018 to November 2019. A subset of patients with near\u2010complete\/complete reperfusion (expanded thrombolysis in cerebral infarction [eTICI] 2c\u20133) was used to compare the pre\u2010procedural prediction of final infarct volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this analysis of 242 patients with LVOS, RAPID and Viz CTP relative cerebral blood flow (rCBF) &lt;\u200930% values had substantial agreement (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.767 [95% confidence interval [CI]\u2009=\u20090.71\u20130.81]) as well as for RAPID and e\u2010CTP (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.668 [95% CI\u2009=\u20090.61\u20130.71]). Excellent agreement was seen for time to maximum of the residue function (<jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub>) &gt;\u20096\u2009seconds between RAPID and Viz CTP (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.811 [95% CI\u2009=\u20090.76\u20130.84]) and substantial for RAPID and e\u2010CTP (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.749 [95% CI\u2009=\u20090.69\u20130.79]). Final infarct volume (FIV) prediction (n\u2009=\u2009136) was substantial in all 3 packages (RAPID <jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.744; Viz CTP <jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.711; and e\u2010CTP <jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.600).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Perfusion parametric maps of the RAPID, Viz CTP, and e\u2010CTP software have substantial agreement in predicting final infarct volume in near\u2010completely\/completely reperfused patients. ANN NEUROL 2023;94:848\u2013855<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.26748","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T13:24:05Z","timestamp":1690291445000},"page":"848-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Comparison of CT Perfusion Software Packages for Thrombectomy Eligibility"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0300-6355","authenticated-orcid":false,"given":"Leonardo","family":"Pisani","sequence":"first","affiliation":[{"name":"Radiology Department St. Vincent Hospital  Worcester MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1884-2196","authenticated-orcid":false,"given":"Diogo C.","family":"Haussen","sequence":"additional","affiliation":[{"name":"Marcus Stroke and Neuroscience Center, Grady Memorial Hospital and Department of Neurology Emory University School of Medicine  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7393-9989","authenticated-orcid":false,"given":"Mahmoud","family":"Mohammaden","sequence":"additional","affiliation":[{"name":"Marcus Stroke and Neuroscience Center, Grady Memorial Hospital and Department of Neurology Emory University School of Medicine  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9353-1219","authenticated-orcid":false,"given":"Catarina","family":"Perry da Camara","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5399-0170","authenticated-orcid":false,"given":"Dinesh V.","family":"Jillella","sequence":"additional","affiliation":[{"name":"Marcus Stroke and Neuroscience Center, Grady Memorial Hospital and Department of Neurology Emory University School of Medicine  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-0882","authenticated-orcid":false,"given":"Gabriel M.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Marcus Stroke and Neuroscience Center, Grady Memorial Hospital and Department of Neurology Emory University School of Medicine  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Bouslama","sequence":"additional","affiliation":[{"name":"Marcus Stroke and Neuroscience Center, Grady Memorial Hospital and Department of Neurology Emory University School of Medicine  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-1930","authenticated-orcid":false,"given":"Alhamza","family":"Al\u2010Bayati","sequence":"additional","affiliation":[{"name":"UPMC Stroke Institute, Department of Neurology &amp; Neurosurgery University of Pittsburgh School of Medicine  Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Prater","sequence":"additional","affiliation":[{"name":"Grady Memorial Hospital, Department of Radiology Emory University School of Medicine  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-2999","authenticated-orcid":false,"given":"Bernardo","family":"Liberato","sequence":"additional","affiliation":[{"name":"Marcus Stroke and Neuroscience Center, Grady Memorial Hospital and Department of Neurology Emory University School of Medicine  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Frankel","sequence":"additional","affiliation":[{"name":"Marcus Stroke and Neuroscience Center, Grady Memorial Hospital and Department of Neurology Emory University School of Medicine  Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-153X","authenticated-orcid":false,"given":"Raul G.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"UPMC Stroke Institute, Department of Neurology &amp; 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