{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:58:41Z","timestamp":1792277921934,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1183032"],"award-info":[{"award-number":["1183032"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA055489"],"award-info":[{"award-number":["R21DA055489"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV\n                    <jats:italic>pol<\/jats:italic>\n                    DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy. ANN NEUROL 2023;94:798\u2013802\n                  <\/jats:p>","DOI":"10.1002\/ana.26750","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T09:15:35Z","timestamp":1690362935000},"page":"798-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-0451","authenticated-orcid":false,"given":"Thomas A.","family":"Angelovich","sequence":"first","affiliation":[{"name":"Infectious and Inflammatory Diseases, School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"},{"name":"Life Sciences Discipline Burnet Institute  Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases The University of Melbourne at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9683-8905","authenticated-orcid":false,"given":"Catherine R.","family":"Cochrane","sequence":"additional","affiliation":[{"name":"Infectious and Inflammatory Diseases, School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"},{"name":"Department of Medicine, The Royal Melbourne Hospital The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Infectious and Inflammatory Diseases, School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Tumpach","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The University of Melbourne at the Peter Doherty Institute for Infection and Immunity  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-8574","authenticated-orcid":false,"given":"Sarah J.","family":"Byrnes","sequence":"additional","affiliation":[{"name":"Infectious and Inflammatory Diseases, School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2087-2717","authenticated-orcid":false,"given":"Janna","family":"Jamal Eddine","sequence":"additional","affiliation":[{"name":"Infectious and Inflammatory Diseases, School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Waring","sequence":"additional","affiliation":[{"name":"Infectious and Inflammatory Diseases, School of Health and Biomedical Sciences RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8549-0023","authenticated-orcid":false,"given":"Kathleen","family":"Busman\u2010Sahay","sequence":"additional","affiliation":[{"name":"Vaccine and Gene Therapy Institute, Oregon Health &amp; 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