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We used an edge\u2010centric approach combined with motif analysis to evaluate higher\u2010order communication patterns of brain networks in migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated edge\u2010centric metrics in 108 interictal migraine patients and 71 healthy controls. We parcellated the brain into networks using independent component analysis. We applied edge graph construction, k\u2010means clustering, community overlap detection, graph\u2010theory\u2010based evaluations, and clinical correlation analysis. We conducted motif analysis to explore the interactions among regions, and a classification model to test the specificity of edge\u2010centric results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The normalized entropy of lateral thalamus was significantly increased in migraine, which was positively correlated with the baseline headache duration, and negatively correlated with headache duration reduction following preventive medications at 3\u2010month follow\u2010up. Network\u2010wise entropy of the sensorimotor network was significantly elevated in migraine. The community similarity between lateral thalamus and postcentral gyrus was enhanced in migraine. Migraine patients showed overrepresented L\u2010shape and diverse motifs, and underrepresented forked motifs with lateral thalamus serving as the reference node. Furthermore, migraine patients presented with overrepresented L\u2010shape triads, where the postcentral gyrus shared different edges with the lateral thalamus. The classification model showed that entropy of the lateral thalamus had the highest discriminative power, with an area under the curve of 0.86.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our findings indicated an abnormal higher\u2010order thalamo\u2013cortical communication pattern in migraine patients. The thalamo\u2013cortical\u2013somatosensory disturbance of concerted working may potentially lead to aberrant information flow and deficit pain processing of migraine. ANN NEUROL 2023;94:1168\u20131181<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.26783","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:20:26Z","timestamp":1693210826000},"page":"1168-1181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Abnormal Thalamo\u2013Cortical Interactions in Overlapping Communities of Migraine: An Edge Functional Connectivity Study"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-2531","authenticated-orcid":false,"given":"Wei","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Neurology First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enchao","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology Thomas Jefferson University  Philadelphia PA 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