{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:02:34Z","timestamp":1788930154981,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["101071900"],"award-info":[{"award-number":["101071900"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Brain lesions sometimes induce a failure of recognition of one's own deficits (anosognosia). Lack of deficit awareness may underlie damage of modality\u2010specific systems, for example, visual cortex for visual anosognosia or motor\/premotor cortex for motor anosognosia. However, focal lesions induce widespread remote structural and functional disconnection, and anosognosia, independent of modality, may also involve common neural mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we study the neural correlates of Anton syndrome (AS), anosognosia of blindness, and compare them with anosognosia for hemiplegia to test whether they share different or common mechanisms. We measured both local damage and patterns of structural\u2013functional disconnection as predicted from healthy normative atlases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AS depends on bilateral striate and extrastriate occipital damage, and disconnection of ventral and dorsal frontoparietal regions involved in attention control. Visual and motor anosognosia each share damage of modality\u2010specific regions, but also involve the disruption of white matter tracts, leading to functional disconnection within dorsal frontal\u2013parietal regions that play critical roles in motor control, visuospatial attention, and multisensory integration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>These results reveal the unique shared combination of content\u2010specific and supramodal mechanisms in anosognosia. ANN NEUROL 2024;95:90\u2013103<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.26791","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:20:04Z","timestamp":1694712004000},"page":"90-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Convergence of Visual and Motor Awareness in Human Parietal Cortex"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-7741","authenticated-orcid":false,"given":"Elena","family":"Monai","sequence":"first","affiliation":[{"name":"Neurological Clinic, Department of Neuroscience University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Pini","sequence":"additional","affiliation":[{"name":"Padua Neuroscience Center University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Palacino","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Department of Neuroscience University of Padua  Padua Italy"},{"name":"Neurological Clinic University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bisio","sequence":"additional","affiliation":[{"name":"Department of Information Engineering University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bernocchi","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Department of Neuroscience University of Padua  Padua Italy"},{"name":"Tor Vergata Neurological Clinic University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1273-7566","authenticated-orcid":false,"given":"Alessandro","family":"Salvalaggio","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Department of Neuroscience University of Padua  Padua Italy"},{"name":"Padua Neuroscience Center University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Corbetta","sequence":"additional","affiliation":[{"name":"Neurological Clinic, Department of Neuroscience University of Padua  Padua Italy"},{"name":"Padua Neuroscience Center University of Padua  Padua Italy"},{"name":"Venetian Institute of Molecular Medicine  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"The study of anosognosia","author":"Prigatano GP","year":"2010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2011.12.012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02126945"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000682"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12064"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2011.7.2.96"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/241715"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.198858"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/474952"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4076\/1752-1947-3-9028"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4236\/jbbs.2012.23045"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(86)90092-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110625"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giy004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab259"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa156"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2020.00021"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46075"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv228"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26709"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25618"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24845"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.02.027"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab119"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1001-3"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.127"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/306075"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2004.08.004"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-009-0179-7"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr099"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/nav.3800020109"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.017"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-061010-113731"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn755"},{"key":"e_1_2_9_39_1","first-page":"1","article-title":"How do you feel\u2014now? The anterior insula and human awareness","volume":"1","author":"Critchley HD","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.44"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.03.018"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1706158"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0753-5"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814117115"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11353-z"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.26791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T10:47:36Z","timestamp":1710845256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.26791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/ana.26791"],"URL":"https:\/\/doi.org\/10.1002\/ana.26791","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,11]]},"assertion":[{"value":"2023-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}