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We assessed the association of the timing of AF detection and insular involvement with the risk of embolic events after acute ischemic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Acute ischemic stroke patients with AF who underwent brain magnetic resonance imaging at baseline were enrolled. Patients were classified according to the timing of AF detection (AF detected after stroke [AFDAS] or known AF [KAF]) and insular involvement. The primary outcome was embolic events defined as recurrent ischemic stroke, transient ischemic attack, and systemic embolism within 90\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1,548 patients, 360 had AFDAS with insular cortex lesions (+I), 409 had AFDAS without insular cortex lesions (\u2212I), 349 had KAF+I, and 430 had KAF\u2212I. Cumulative incidence rates of embolic events at 90\u2009days in patients with AFDAS+I, AFDAS\u2212I, KAF+I, and KAF\u2212I were 0.8%, 3.5%, 4.9%, and 3.3%, respectively. Patients with AFDAS\u2212I (adjusted hazard ratio 5.04, 95% confidence interval 1.43\u201317.75), KAF+I (6.18, 1.78\u201321.46), and KAF\u2212I (5.26, 1.48\u201318.69) had a significantly higher risk of embolic events than those with AFDAS+I.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Acute ischemic stroke patients with AFDAS and insular cortex lesions had a lower risk of embolic events than those who had AFDAS without insular cortex lesions or those with KAF, regardless of insular involvement. 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