{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:47:19Z","timestamp":1790178439908,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI23C0092"],"award-info":[{"award-number":["HI23C0092"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102023\u201000265377"],"award-info":[{"award-number":["RS\u20102023\u201000265377"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated whether hippocampal perfusion changes are associated with cognitive decline, motor deficits, and the risk of dementia conversion in patients with Parkinson disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We recruited patients with newly diagnosed and nonmedicated PD and healthy participants who underwent dual phase\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010N\u2010(3\u2010fluoropropyl)\u20102\u03b2\u2010carboxymethoxy\u20103\u03b2\u2010(4\u2010iodophenyl) nortropane positron emission tomography scans. Patients were classified into 3 groups according to hippocampal perfusion measured by standard uptake value ratios (SUVRs): (1) PD hippocampal hypoperfusion group (1 standard deviation [SD] below the mean hippocampal SUVR of healthy controls; PD\u2010hippo\u2010hypo), (2) PD hippocampal hyperperfusion group (1 SD above the mean; PD\u2010hippo\u2010hyper), and (3) the remaining patients (PD\u2010hippo\u2010normal). We compared the baseline cognitive performance, severity of motor deficits, hippocampal volume, striatal dopamine transporter (DAT) availability, and risk of dementia conversion among the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 235 patients (PD\u2010hippo\u2010hypo, n\u2009=\u200921; PD\u2010hippo\u2010normal,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009157; PD\u2010hippo\u2010hyper,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200957) and 48 healthy participants. Patients in the PD\u2010hippo\u2010hypo group were older and had smaller hippocampal volumes than those in the other PD groups. The PD\u2010hippo\u2010hypo group showed less severely decreased DAT availability in the putamen than the other groups despite similar severities of motor deficit. The PD\u2010hippo\u2010hypo group had a higher risk of dementia conversion compared to the PD\u2010hippo\u2010normal (hazard ratio\u2009=\u20092.59,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) and PD\u2010hippo\u2010hyper (hazard ratio\u2009=\u20093.73,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) groups, despite similar cognitive performance at initial assessment between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Hippocampal hypoperfusion may indicate a reduced capacity to cope with neurodegenerative processes in terms of the development of motor deficits and cognitive decline in patients with PD. ANN NEUROL 2024;95:388\u2013399<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.26827","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T09:05:48Z","timestamp":1699952748000},"page":"388-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson Disease: An\n                    <scp>\n                      Early Phase\n                      <sup>18<\/sup>\n                      F\u2010FP\u2010CIT Positron Emission Tomography\n                    <\/scp>\n                    Study"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-6132","authenticated-orcid":false,"given":"Min Young","family":"Chun","sequence":"first","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"},{"name":"Department of Neurology, Yongin Severance Hospital Yonsei University Health System  Yongin South Korea"},{"name":"Yonsei Beyond Lab  Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-3199","authenticated-orcid":false,"given":"Seok Jong","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"},{"name":"Department of Neurology, Yongin Severance Hospital Yonsei University Health System  Yongin South Korea"},{"name":"Yonsei Beyond Lab  Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Hong","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology  Daejeon South Korea"},{"name":"Institute for Health Science Technology Korea Advanced Institute of Science and Technology  Daejeon South Korea"},{"name":"Department of Radiology Yeungnam University College of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"},{"name":"Department of Physiology Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-4390","authenticated-orcid":false,"given":"Seong Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"},{"name":"Department of Neurology Inje University Sanggye Paik Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"Biostatistics Collaboration Unit Yonsei University College of Medicine  Seoul South 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