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Participants completed the multiday Boston Remote Assessment for Neurocognitive Health (BRANCH) for 12\u2009min\/day on personal devices (ie, smartphones, laptops), which captures the trajectory of daily learning of the same content on 3 repeated tests (Digit Signs, Groceries\u2010Prices, Face\u2010Name). Learning is computed as a composite of accuracy across all 3 measures. Participants also completed standard in\u2010clinic cognitive tests as part of the Preclinical Alzheimer's Cognitive Composite (PACC\u20105), with 123 participants undergoing PACC\u20105 follow\u2010up after 1.07 (standard deviation\u2009=\u20090.25) years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the cross\u2010section, there were no statistically significant differences in performance between A\u03b2+\/\u2212 participants on any standard in\u2010clinic cognitive tests (eg, PACC\u20105) or on day 1 of multiday BRANCH. A\u03b2+ participants exhibited diminished 7\u2010day learning curves on multiday BRANCH after 4\u2009days of testing relative to A\u03b2\u2212 participants (Cohen\n                      <jats:italic>d<\/jats:italic>\n                      \u2009=\u20090.49, 95% confidence interval\u2009=\u20090.10\u20130.87). Diminished learning curves were associated with greater annual PACC\u20105 decline (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Very early A\u03b2\u2010related memory declines can be revealed by assessing learning over days, suggesting that failures in memory consolidation predate other conventional amnestic deficits in AD. Repeated digital memory assessments, increasingly feasible and uniquely able to assess memory consolidation over short time periods, have the potential to be transformative for detecting the earliest cognitive changes in preclinical AD. ANN NEUROL 2024;95:507\u2013517<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.26833","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T19:17:07Z","timestamp":1700767027000},"page":"507-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Early Detection of Amyloid\u2010Related Changes in Memory among Cognitively Unimpaired Older Adults with Daily Digital Testing"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1687-4370","authenticated-orcid":false,"given":"Kathryn V.","family":"Papp","sequence":"first","affiliation":[{"name":"Center for Alzheimer Research and Treatment, Department of Neurology Brigham and Women's Hospital, Harvard Medical School  Boston MA USA"},{"name":"Department of Neurology Massachusetts General Hospital, Harvard Medical School  Boston MA 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