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In addition to liver transplantation, several groundbreaking disease\u2010modifying drugs (DMDs) such as tetrameric TTR stabilizers and <jats:italic>TTR<\/jats:italic> gene\u2010silencing therapies have been developed for ATTRv amyloid polyneuropathy. They were based on a working hypothesis of the mechanisms of ATTRv amyloid formation. In this retrospective cohort study, we investigated survival of all 201 consecutive patients with ATTRv amyloidosis in our center. The effects of DMDs on survival improvements were significant not only in early\u2010onset patients but also in late\u2010onset patients. 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