{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:08:14Z","timestamp":1790122094516,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AG016574"],"award-info":[{"award-number":["AG016574"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AG62677"],"award-info":[{"award-number":["AG62677"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["NS100620"],"award-info":[{"award-number":["NS100620"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AG056639"],"award-info":[{"award-number":["AG056639"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AG071754"],"award-info":[{"award-number":["AG071754"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV\u201018\u20100547"],"award-info":[{"award-number":["APVV\u201018\u20100547"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV\u201022\u20100279"],"award-info":[{"award-number":["APVV\u201022\u20100279"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010277","name":"Little Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) to predict the development of Parkinson disease (PD) and dementia with Lewy bodies (DLB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      Method\n                      <jats:bold>s<\/jats:bold>\n                    <\/jats:title>\n                    <jats:p>In this multicenter study of the International RBD study group, 173 patients (mean age 70.5\u2009\u00b1\u20096.3\u2009years, 70.5% males) with polysomnography\u2010confirmed RBD who eventually phenoconverted to overt alpha\u2010synucleinopathy (RBD due to synucleinopathy) were enrolled, and underwent baseline presynaptic dopaminergic imaging and clinical assessment, including motor, cognitive, olfaction, and constipation evaluation. For comparison, 232 RBD non\u2010phenoconvertor patients (67.6\u2009\u00b1\u20097.1\u2009years, 78.4% males) and 160 controls (68.2\u2009\u00b1\u20097.2\u2009years, 53.1% males) were enrolled. Imaging and clinical features were analyzed by machine learning to determine predictors of phenoconversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Machine learning analysis showed that clinical data alone poorly predicted phenoconversion. Presynaptic dopaminergic imaging significantly improved the prediction, especially in combination with clinical data, with 77% sensitivity and 85% specificity in differentiating RBD due to synucleinopathy from non phenoconverted RBD patients, and 85% sensitivity and 86% specificity in discriminating PD\u2010converters from DLB\u2010converters. Quantification of presynaptic dopaminergic imaging showed that an empirical\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score cutoff of \u22121.0 at the most affected hemisphere putamen characterized RBD due to synucleinopathy patients, while a cutoff of \u22121.0 at the most affected hemisphere putamen\/caudate ratio characterized PD\u2010converters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Clinical data alone poorly predicted phenoconversion in RBD due to synucleinopathy patients. Conversely, presynaptic dopaminergic imaging allows a good prediction of forthcoming phenoconversion diagnosis. This finding may be used in designing future disease\u2010modifying trials. ANN NEUROL 2024;95:1178\u20131192<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.26902","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T10:24:26Z","timestamp":1710152666000},"page":"1178-1192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Presynaptic Dopaminergic Imaging Characterizes Patients with\n                    <scp>REM<\/scp>\n                    Sleep Behavior Disorder Due to Synucleinopathy"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-6069","authenticated-orcid":false,"given":"Dario","family":"Arnaldi","sequence":"first","affiliation":[{"name":"Department of Neuroscience (DINOGMI) University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Mattioli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience (DINOGMI) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Raffa","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pardini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience (DINOGMI) University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5667-204X","authenticated-orcid":false,"given":"Federico","family":"Massa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience (DINOGMI) University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-8271","authenticated-orcid":false,"given":"Alex","family":"Iranzo","sequence":"additional","affiliation":[{"name":"Neurology Service, Sleep Disorder Centre, Hospital Cl\u00ednic Barcelona Universitat de Barcelona, IDIBAPS, CIBERNED: CB06\/05\/0018\u2010ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Perissinotti","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Service, Hospital Cl\u00ednic Barcelona, Biomedical Research Networking Centre of Bioengineering Biomaterials and Nanomedicine (CIBER\u2010BBN), ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Ni\u00f1erola\u2010Baiz\u00e1n","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Service, Hospital Cl\u00ednic Barcelona, Biomedical Research Networking Centre of Bioengineering Biomaterials and Nanomedicine (CIBER\u2010BBN), ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Gaig","sequence":"additional","affiliation":[{"name":"Neurology Service, Sleep Disorder Centre, Hospital Cl\u00ednic Barcelona Universitat de Barcelona, IDIBAPS, CIBERNED: CB06\/05\/0018\u2010ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Serradell","sequence":"additional","affiliation":[{"name":"Neurology Service, Sleep Disorder Centre, Hospital Cl\u00ednic Barcelona Universitat de Barcelona, IDIBAPS, CIBERNED: CB06\/05\/0018\u2010ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaia","family":"Mu\u00f1oz\u2010Lopetegi","sequence":"additional","affiliation":[{"name":"Neurology Service, Sleep Disorder Centre, Hospital Cl\u00ednic Barcelona Universitat de Barcelona, IDIBAPS, CIBERNED: CB06\/05\/0018\u2010ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"May\u00e0","sequence":"additional","affiliation":[{"name":"Neurology Service, Sleep Disorder Centre, Hospital Cl\u00ednic Barcelona Universitat de Barcelona, IDIBAPS, CIBERNED: CB06\/05\/0018\u2010ISCIII  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-1332","authenticated-orcid":false,"given":"Claudio","family":"Liguori","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome Tor Vergata  Rome Italy"},{"name":"Sleep Medicine Center, Neurology Unit University Hospital of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Placidi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine University of Rome Tor Vergata  Rome Italy"},{"name":"Sleep Medicine Center, Neurology Unit University Hospital of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Chiaravalloti","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention University of Rome \u201cTor Vergata\u201d  Rome Italy"},{"name":"IRCCS Neuromed  Pozzilli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"\u0160onka","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Du\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zogala","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Trnka","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Medicine, First Faculty of Medicine Charles University and General University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toji","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6535-8260","authenticated-orcid":false,"given":"Tomoyuki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology Dokkyo Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Center of Sleep Medicine Dokkyo Medical University Hospital  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Puligheddu","sequence":"additional","affiliation":[{"name":"Sleep Disorder Center, Department of Public Health and Clinical and Molecular Medicine University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Figorilli","sequence":"additional","affiliation":[{"name":"Sleep Disorder Center, Department of Public Health and Clinical and Molecular Medicine University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Serra","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Medical Science and Public Health University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele T.","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Neurology, Nuffield Department of Clinical Neurosciences Oxford University  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes C.","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Neurology, Nuffield Department of Clinical Neurosciences Oxford University  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Bes","sequence":"additional","affiliation":[{"name":"Clinic of Sleep &amp; Chronomedicine, St. Hedwig\u2010Hospital  Berlin Germany"},{"name":"Institute of Physiology, Sleep Research &amp; Clinical Chronobiology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-5878","authenticated-orcid":false,"given":"Dieter","family":"Kunz","sequence":"additional","affiliation":[{"name":"Clinic of Sleep &amp; Chronomedicine, St. Hedwig\u2010Hospital  Berlin Germany"},{"name":"Institute of Physiology, Sleep Research &amp; Clinical Chronobiology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Cochen De Cock","sequence":"additional","affiliation":[{"name":"Sleep and Neurology Department, Beau Soleil Clinic  Montpellier France"},{"name":"EuroMov Digital Health in Motion, Univ Montpellier, IMT Mines Ales  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"de Verbizier","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit University Hospital of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna  Bologna Italy"},{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio\u2010Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1739-6139","authenticated-orcid":false,"given":"Elena","family":"Antelmi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9692-2218","authenticated-orcid":false,"given":"Michele","family":"Terzaghi","sequence":"additional","affiliation":[{"name":"Sleep Medicine and Epilepsy Unit IRCCS Mondino Foundation  Pavia Italy"},{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bossert","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit ICS Maugeri SpA SB IRCCS  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00edna","family":"Kulcs\u00e1rov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology P. J. Safarik University  Kosice Slovak Republic"},{"name":"Department of Neurology University Hospital of L. Pasteur  Kosice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Business and Management LUISS University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Department of Environment and Health Istituto Superiore di Sanit\u00e0 (Italian National Institute of Health)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pagani","sequence":"additional","affiliation":[{"name":"Institute of Cognitive Sciences and Technologies Consiglio Nazionale delle Ricerche  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Nobili","sequence":"additional","affiliation":[{"name":"Department of Neuroscience (DINOGMI) University of Genoa  Genoa Italy"},{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Morbelli","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"},{"name":"Nuclear Medicine Unit, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"International REM Sleep Behavior Disorder Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz030"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2021.04.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30449-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2018.09.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00404-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00405-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203395"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202867"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14664"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00176-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25026"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa365"},{"key":"e_1_2_9_14_1","volume-title":"International classification of sleep disorders","author":"AASM","year":"2014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington DC2013.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1267-x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-04817-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/tomography7040081"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.239418"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-06069-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21198"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26435"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26062"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20153"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.09.025"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.014"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(84)90269-5"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.1.39"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjj037"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1936.tb02137.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-45528-0"},{"key":"e_1_2_9_37_1","volume-title":"Classification and regression trees","author":"Breiman L","year":"1984"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00994018"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIT.1967.1053964"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/treephys\/tpab106"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad021"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28468"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.2489-18"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70152-1"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22899"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.08.025"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000123248.39847.1D"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.189266"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26298"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"e_1_2_9_51_1","article-title":"Dopamine transporter imaging for the diagnosis of dementia with Lewy bodies","volume":"30","author":"McCleery J","year":"2015","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.26902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T05:47:18Z","timestamp":1715924838000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.26902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/ana.26902"],"URL":"https:\/\/doi.org\/10.1002\/ana.26902","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,11]]},"assertion":[{"value":"2023-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}