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Patients with CBS and PSP were divided into AD\u2010positive (CBS\/PSP\u2010AD) and AD\u2010negative (CBS\/PSP\u2010noAD) groups based on fluid biomarkers and amyloid PET scans. Cognitive, motor, and depression scores; AD fluid biomarkers (cerebrospinal p\u2010tau, t\u2010tau, and amyloid\u2010beta, and plasma ptau\u2010217); and neuroimaging data (amyloid PET, MRI and fMRI) were collected. Clinical features, whole\u2010brain gray matter volume and functional networks connectivity were compared across groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were analyzed from 87 CBS\/PSP\u2010noAD and 23 CBS\/PSP\u2010AD, 18 AD, and 30 healthy controls. CBS\/PSP\u2010noAD showed worse performance in comparison to CBS\/PSP\u2010AD in the PSPRS [mean(SD): 34.8(15.8) vs 23.3(11.6)] and the UPDRS scores [mean(SD): 34.2(17.0) vs 21.8(13.3)]. CBS\/PSP\u2010AD demonstrated atrophy in AD signature areas and brainstem, while CBS\/PSP\u2010noAD patients displayed atrophy in frontal and temporal areas, globus pallidus, and brainstem compared to healthy controls. The default mode network showed greatest disconnection in CBS\/PSP\u2010AD compared with CBS\/PSP\u2010no AD and controls. The thalamic network connectivity was most affected in CBS\/PSP\u2010noAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>AD biomarker positivity may modulate the clinical presentation of CBS\/PSP, with evidence of distinctive structural and functional brain changes associated with the AD pathology\/co\u2010pathology. ANN NEUROL 2024;96:99\u2013109<\/jats:p><\/jats:sec>","DOI":"10.1002\/ana.26930","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T13:05:07Z","timestamp":1712322307000},"page":"99-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Evaluating the Effect of Alzheimer's Disease\u2010Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9739-5018","authenticated-orcid":false,"given":"Indira","family":"Garcia\u2010Cordero","sequence":"first","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Anastassiadis","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Khoja","sequence":"additional","affiliation":[{"name":"University Health Network Memory Clinic  Toronto ON Canada"},{"name":"Neurology Division, Medical Department, Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alonso","family":"Morales\u2010Rivero","sequence":"additional","affiliation":[{"name":"University Health Network Memory Clinic  Toronto ON Canada"},{"name":"ABC Medical Center  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simrika","family":"Thapa","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Vasilevskaya","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Davenport","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-792X","authenticated-orcid":false,"given":"Vishaal","family":"Sumra","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blas","family":"Couto","sequence":"additional","affiliation":[{"name":"Rossy PSP Program University Health Network and the University of Toronto  Toronto ON Canada"},{"name":"The Edmond J. 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