{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:33:51Z","timestamp":1773329631949,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["MDA510281"],"award-info":[{"award-number":["MDA510281"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Quantitative muscle fat fraction (FF) responsiveness is lower in younger Charcot\u2013Marie\u2013Tooth disease type 1A (CMT1A) patients with lower baseline calf\u2010level FF. We investigated the practicality, validity, and responsiveness of foot\u2010level FF in this cohort involving 22 CMT1A patients and 14 controls. The mean baseline foot\u2010level FF was 25.9\u2009\u00b1\u200920.3% in CMT1A patients, and the 365\u2010day FF (<jats:italic>n<\/jats:italic>\u2009=\u200915) increased by 2.0\u2009\u00b1\u20092.4% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 vs controls). Intrinsic foot\u2010level FF demonstrated large responsiveness (12\u2010month standardized response mean (SRM) of 0.86) and correlated with the CMT examination score (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.58, <jats:italic>P<\/jats:italic>\u2009=\u20090.01). Intrinsic foot\u2010level FF has the potential to be used as a biomarker in future clinical trials involving younger CMT1A patients. ANN NEUROL 2024;96:170\u2013174<\/jats:p>","DOI":"10.1002\/ana.26934","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T11:59:08Z","timestamp":1713009548000},"page":"170-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantitative Foot Muscle Magnetic Resonance Imaging Reliably Measures Disease Progression in Children and Adolescents with Charcot\u2013Marie\u2013Tooth Disease Type 1A"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-3573","authenticated-orcid":false,"given":"Carolynne M.","family":"Doherty","sequence":"first","affiliation":[{"name":"Center for Neuromuscular Diseases, Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige","family":"Howard","sequence":"additional","affiliation":[{"name":"Roy and Lucille Carver College of Medicine, University of Iowa  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9514-1516","authenticated-orcid":false,"given":"Luke F.","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Center for Neuromuscular Diseases, Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Zuccarino","sequence":"additional","affiliation":[{"name":"Roy and Lucille Carver College of Medicine, University of Iowa  Iowa City IA USA"},{"name":"Fondazione Serena Onlus, Centro Clinico NeMO Trento  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Wastling","sequence":"additional","affiliation":[{"name":"Lysholm Department of Radiology National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelin","family":"Milev","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Center, Great Ormond Street Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Banks","sequence":"additional","affiliation":[{"name":"Department of Radiology Great Ormond Street Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachit","family":"Shah","sequence":"additional","affiliation":[{"name":"Lysholm Department of Radiology National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Zafeiropoulos","sequence":"additional","affiliation":[{"name":"Lysholm Department of Radiology National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine J.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Roy and Lucille Carver College of Medicine, University of Iowa  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sarkozy","sequence":"additional","affiliation":[{"name":"Dubowitz Neuromuscular Center, Great Ormond Street Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany","family":"Grider","sequence":"additional","affiliation":[{"name":"Roy and Lucille Carver College of Medicine, University of Iowa  Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawna M. 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