{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:41:17Z","timestamp":1769092877958,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Brain networks mediating vestibular perception of self\u2010motion overlap with those mediating balance. A systematic mapping of vestibular perceptual pathways in the thalamus may reveal new brain modulation targets for improving balance in neurological conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we systematically report how magnetic resonance\u2010guided focused ultrasound surgery of the nucleus ventralis intermedius of the thalamus commonly evokes transient patient\u2010reported illusions of self\u2010motion. In 46 consecutive patients, we linked the descriptions of self\u2010motion to sonication power and 3\u2010dimensional (3D) coordinates of sonication targets. Target coordinates were normalized using a standard atlas, and a 3D model of the nucleus ventralis intermedius and adjacent structures was created to link sonication target to the illusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 63% of patients reported illusions of self\u2010motion, which were more likely with increased sonication power and with targets located more inferiorly along the rostrocaudal axis. Higher power and more inferiorly targeted sonications increased the likelihood of experiencing illusions of self\u2010motion by 4 and 2 times, respectively (odds ratios\u2009=\u20094.03 for power, 2.098 for location).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>The phenomenon of magnetic vestibular stimulation is the most plausible explanation for these illusions of self\u2010motion. Temporary unilateral modulation of vestibular pathways (via magnetic resonance\u2010guided focused ultrasound) unveils the central adaptation to the magnetic field\u2010induced peripheral vestibular bias, leading to an explicable illusion of motion. Consequently, systematic mapping of vestibular perceptual pathways via magnetic resonance\u2010guided focused ultrasound may reveal new intracerebral targets for improving balance in neurological conditions. 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