{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T06:06:03Z","timestamp":1788069963691,"version":"build-2784847793"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Alice in Wonderland syndrome (AIWS) profoundly affects human perception of size and scale, particularly regarding one's own body and the environment. Its neuroanatomical basis has remained elusive, partly because brain lesions causing AIWS can occur in different brain regions. Here, we aimed to determine if brain lesions causing AIWS map to a distributed brain network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective case\u2013control study analyzing 37 cases of lesion\u2010induced AIWS identified through systematic literature review was conducted. Using resting\u2010state functional connectome data from 1,000 healthy individuals, the whole\u2010brain connections of each lesion were estimated and contrasted with those from a control dataset comprising 1,073 lesions associated with 25 other neuropsychiatric syndromes. Additionally, connectivity findings from lesion\u2010induced AIWS cases were compared with functional neuroimaging results from 5 non\u2010lesional AIWS cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AIWS\u2010associated lesions were located in various brain regions with minimal overlap (\u226433%). However, the majority of lesions (\u226585%) demonstrated shared connectivity to the right extrastriate body area, known to be selectively activated by viewing body part images, and the inferior parietal cortex, involved in size and scale judgements. This pattern was uniquely characteristic of AIWS when compared with other neuropsychiatric disorders (family\u2010wise error\u2010corrected\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.05) and consistent with functional neuroimaging observations in AIWS due to nonlesional causes (median correlation\n                      <jats:italic>r\u2009=<\/jats:italic>\n                      \u20090.56, interquartile range 0.24).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>AIWS\u2010related perceptual distortions map to one common brain network, encompassing regions critical for body representation and size\u2010scale processing. These findings lend insight into the neuroanatomical localization of higher\u2010order perceptual functions, and may inform future therapeutic strategies for perceptual disorders. ANN NEUROL 2024;96:662\u2013674<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.27015","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T08:06:12Z","timestamp":1719821172000},"page":"662-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lesions Causing Alice in Wonderland Syndrome Map to a Common Brain Network Linking Body and Size Perception"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-1268","authenticated-orcid":false,"given":"Maximilian U.","family":"Friedrich","sequence":"first","affiliation":[{"name":"Center for Brain Circuit Therapeutics, Brigham &amp; Women's Hospital  Boston MA"},{"name":"Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah C.","family":"Baughan","sequence":"additional","affiliation":[{"name":"Department of Psychology Brigham Young 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