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Although autologous hematopoietic stem cell transplant is an effective treatment modality, it is an intensive chemotherapy\u2010based therapy with a range of short\u2010 and long\u2010term side\u2010effects. Chimeric antigen receptor T\u2010cell therapy (CAR\u2010T) has revolutionized the treatment of B\u2010cell and other hematological malignancies, conferring long\u2010term remission for otherwise refractory diseases. However, the toxicity of this treatment, particularly cytokine release syndrome and immune effector cell\u2010associated neurotoxicity syndrome, and the complexity of production necessitate the need for a high level of specialization at treating centers. Early\u2010phase trials of CAR\u2010T therapies in immune\u2010mediated B cell driven conditions, such as systemic lupus erythematosus, neuromyelitis optica spectrum disorder and myasthenia gravis, have shown dramatic clinical response with few adverse events. Based on the common physiopathology, CAR\u2010T therapy in other immune\u2010mediated neurological disease, including multiple sclerosis, chronic inflammatory polyradiculopathy, autoimmune encephalitis, and stiff person syndrome, might be an effective option for patients, avoiding the need for long\u2010term immunosuppressant medications. It may prove to be a more selective immunoablative approach than autologous hematopoietic stem cell transplant, with potentially increased efficacy and lower adverse events. In this review, we present the state of the art and future directions of the use of CAR\u2010T in such conditions. 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