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The newer antiseizure medication lacosamide is increasingly used in neonates and infants. Neurotoxicity of lacosamide and its combination with levetiracetam was studied in neonatal mice. Animals received single or repeat injections of saline, phenobarbital (75mg\/kg), lacosamide (20\u201340mg\/kg), levetiracetam (100mg\/kg), lacosamide (40mg\/kg)\u2009+\u2009levetiracetam (100mg\/kg) and euthanized at 6 to 30\u2009hours. Cells undergoing apoptosis were increased in the brains of phenobarbital\u2010treated animals. Densities of apoptotic profiles following lacosamide and levetiracetam treatment did not differ from saline\u2010treated controls. Findings suggest that lacosamide, levetiracetam and their combination do not cause apoptosis in developing mouse brains. 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