{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:44:48Z","timestamp":1772545488724,"version":"3.50.1"},"reference-count":134,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS075930"],"award-info":[{"award-number":["R01NS075930"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U24NS075930"],"award-info":[{"award-number":["U24NS075930"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U24NS130600"],"award-info":[{"award-number":["U24NS130600"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Direct oral anticoagulants are the primary stroke prevention option in patients with atrial fibrillation. Anticoagulant use before stroke, however, might inhibit clinician comfort with thrombolysis if a stroke does occur. Resuming anticoagulants after ischemic stroke is also problematic for fear of hemorrhage. We describe extensive literature showing that thrombolysis is safe after stroke with direct anticoagulant use. Early reinstitution of direct anticoagulant treatment is associated with lower risk of embolic recurrence and lower hemorrhage risk. The use of direct anticoagulants before, during, and after thrombolysis appears to be safe and is likely to promote improved outcomes after ischemic stroke. ANN NEUROL 2024;96:871\u2013886<\/jats:p>","DOI":"10.1002\/ana.27058","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T09:58:58Z","timestamp":1726048738000},"page":"871-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Before, during, and after: An Argument for Safety and Improved Outcome of Thrombolysis in Acute Ischemic Stroke with Direct Oral Anticoagulant Treatment"],"prefix":"10.1002","volume":"96","author":[{"given":"Sanaz","family":"Monjazeb","sequence":"first","affiliation":[{"name":"Department of Neurology Zilkha Neurogenetic Institute of the Keck School of Medicine  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather V.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neuroscience Zilkha Neurogenetic Institute of the Keck School of Medicine  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-4042","authenticated-orcid":false,"given":"Patrick D.","family":"Lyden","sequence":"additional","affiliation":[{"name":"Department of Neurology Zilkha Neurogenetic Institute of the Keck School of Medicine  Los Angeles CA USA"},{"name":"Department of Physiology and Neuroscience Zilkha Neurogenetic Institute of the Keck School of Medicine  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987319841187"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.02.009"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000046"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-10-200305200-00011"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.1.11"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199003223221232"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00007"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000086"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2007.07.079"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022606"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987321989865"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003074"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9092938"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213379"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310672"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62343-0"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2021.10.001"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310907"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab303"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25700"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09412-y"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.0948"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25917"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-010-0097-2"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144856"},{"key":"e_1_2_15_31_1","article-title":"Considerations for use of direct oral anticoagulants in arterial disease. Res Pract","volume":"5","author":"Siegal DM","year":"2021","journal-title":"Thromb Haemost"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987319832140"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60584-5"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000665"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029749"},{"key":"e_1_2_15_37_1","first-page":"515","article-title":"Administering thrombolysis for acute ischemic stroke in patients taking direct oral anticoagulants: to treat or how to treat. JAMA","volume":"78","author":"Seiffge DJ","year":"2021","journal-title":"Neurology"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2007.067058"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.2.341"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.7.1326"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25383"},{"key":"e_1_2_15_42_1","first-page":"1","article-title":"Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence","volume":"5","author":"Lyden PD","year":"1993","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-002-0051-0"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12434"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20199"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.584920"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.594672"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334578"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.04.008"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319886"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-01-0042"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342307"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.05.003"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1506"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.54.238"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12565"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350570"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355839"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.07.008"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.10.014"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12285"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014560"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-015-2336-5"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2015.76.4.244"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.12.029"},{"key":"e_1_2_15_66_1","first-page":"557","article-title":"Successful intravenous thrombolysis in acute ischaemic stroke in a patient on rivaroxaban treatment","volume":"111","author":"Kawiorski MM, Alonso\u2010Canovas A, de Felipe Mimbrera A, Sainz de la Maza S, Alvarez\u2010Velasco R, Zarza B, Masjuan J.","year":"2014","journal-title":"Thromb Haemost"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.03.029"},{"key":"e_1_2_15_68_1","first-page":"1","article-title":"Intravenous thrombolysis in a patient using factor Xa inhibitor","volume":"7","author":"Korya D","year":"2014","journal-title":"J Vasc Interv Neurol"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009435"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.03.017"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.05.015"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12315"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1159\/000375181"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21917"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006661"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003886"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.88.16_supplement.P4.271"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.03.004"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.615476"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011285"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.07.021"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.015484"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.12.027"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023940"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.06.004"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025809"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.4782"},{"key":"e_1_2_15_88_1","doi-asserted-by":"crossref","unstructured":"JinC HuangRJ.Intravenous tPA (Tissue\u2010Type Plasminogen Activator) in Patients With Acute Ischemic Stroke Taking Non\u2013Vitamin K Antagonist Oral Anticoagulants Preceding Stroke 2018.","DOI":"10.1161\/STROKEAHA.118.022128"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.6160"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.549"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-014-0480-9"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026426"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.031669"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03498-8"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016720"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.625574"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020978345"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.0550"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.046142"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010133"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303048"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873221106043"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23558"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040804"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.226"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005316"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23302"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017751"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-12-0942"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24013"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-08-0631"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567202613666160517122605"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1815-1"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02199.x"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.2.4"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70055-8"},{"key":"e_1_2_15_117_1","first-page":"1677","article-title":"Effect of thrombin on blood brain barrier permeability and its mechanism","volume":"117","author":"Guan JX","year":"2004","journal-title":"Chin Med J"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.5.1020"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688633"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2006.01.002"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000126044.83777.f4"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.99.1.0065"},{"key":"e_1_2_15_123_1","first-page":"8","article-title":"Blood\u2010brain barrier breakdown and repair by Src after thrombin\u2010induced injury","volume":"2010","author":"Liu DZ","year":"2010","journal-title":"Ann Neurol"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0369-12.2012"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-020-00855-4"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01268.x"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1711-1"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.09.049"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11023"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.09.038"},{"key":"e_1_2_15_131_1","first-page":"229","article-title":"Protease activated receptor\u20101 mediates cytotoxicity during ischemia using in vivo and in vitro models","volume":"281","author":"Phan TG","year":"2014","journal-title":"PLoS One"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004488"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12293"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.04.019"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21997"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.27058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T07:36:25Z","timestamp":1729582585000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.27058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":134,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ana.27058"],"URL":"https:\/\/doi.org\/10.1002\/ana.27058","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"assertion":[{"value":"2024-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}