{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:32:53Z","timestamp":1792521173468,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Intravascular lymphoma is a rare subtype of B\u2010cell lymphoma characterized by a clonal proliferation restricted to the lumen of small vessels. Over 50% of patients exhibit central nervous system (CNS) involvement, but diagnosis is often delayed due to the lack of distinctive features. We aimed to identify key phenotypic features for early diagnosis of intravascular lymphoma with CNS involvement through an in\u2010depth cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We built up a multicenter retrospective cohort of 17 patients recruited in collaboration with the French Expert Network for Oculo\u2010Cerebral Lymphomas (LOC network), and retrospectively analyzed data from medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this cohort, 15 of 17 (88%) patients developed focal neurological episodes, often fluctuating and\/or recurrent, with a sudden onset in 68% of episodes, suggesting a vascular origin. Rapid cognitive deterioration occurred in 15 of 17 (88%) patients, psychiatric manifestations in 8 of 17 (47%), and \u201cB signs\u201d in 14 of 17 (82%). Brain MRI showed polymorphic FLAIR hyperintensities in 14 of 16 (87%) patients, and DWI\u2010positive lesions in 13 of 16 (81%) of patients, which accumulated over time and had unusual characteristics for ischemic lesions (progressive growth, persistent DWI\u2010hyperintensity over 1\u2009month, surrounded by a wider FLAIR hyperintensity). Early\u2010onset inflammatory syndrome, and elevated lactate dehydrogenase (LDH) levels were observed in over 90% of cases. Mild and inconsistent meningitis contrasted with a nearly\u2010constant hyperproteinorachia. An increased interleukin 10\/6 ratio over 0,7 was found in 4 of 7 (57%) patients, and skin biopsy led to a pathological diagnosis in 3 of 6 (50%) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>The results of this study highlight \u201cred flags\u201d that could help accelerate the diagnosis of intravascular lymphoma involving the CNS. ANN NEUROL 2025;97:435\u2013448<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.27132","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T03:24:01Z","timestamp":1732764241000},"page":"435-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Unveiling the Clinical and Imaging Signatures of Intravascular Lymphoma of the Central Nervous System: A Multicentric Cohort Study"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4385-7740","authenticated-orcid":false,"given":"Elodie","family":"Berthet","sequence":"first","affiliation":[{"name":"Neurology Departement Lariboisi\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Guillonnet","sequence":"additional","affiliation":[{"name":"Neuroradiology Departement Lariboisi\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Houillier","sequence":"additional","affiliation":[{"name":"Neurooncology Departement Piti\u00e9\u2010Salp\u00e9tri\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Ursu","sequence":"additional","affiliation":[{"name":"Neurooncology Department Saint\u2010Louis Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Soussain","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institut Curie, Site Saint\u2010Cloud, France and INSERM U932 Institut Curie PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Touat","sequence":"additional","affiliation":[{"name":"Neurooncology Departement Piti\u00e9\u2010Salp\u00e9tri\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Gueguen","sequence":"additional","affiliation":[{"name":"Department of Neurology Rothschild Ophthalmologic Foundation  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"de Renzis","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5176-580X","authenticated-orcid":false,"given":"Kevin","family":"Bigaut","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0877-2289","authenticated-orcid":false,"given":"Guido","family":"Ahle","sequence":"additional","affiliation":[{"name":"Department of Neurology Civilian Hospitals Colmar  Colmar France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3459-7741","authenticated-orcid":false,"given":"Pierre","family":"Durozard","sequence":"additional","affiliation":[{"name":"Department of Neurology Ajaccio Hospital  Ajaccio France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Grosset\u2010Janin","sequence":"additional","affiliation":[{"name":"Department of Neurology Annecy\u2010Genevois Hospital  Epagny\u2010Metz\u2010Tessy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Oberic","sequence":"additional","affiliation":[{"name":"Department of Hematology Cancer University Institute of Toulouse Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Department of Hematology Centre Hospitalier de Bretagne Atlantique  Vannes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Pascale","family":"Grandjean","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Molu\u00e7on\u2010Chabrot","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kh\u00ea","family":"Hoang\u2010Xuan","sequence":"additional","affiliation":[{"name":"Neurooncology Departement Piti\u00e9\u2010Salp\u00e9tri\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris, Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8436-6074","authenticated-orcid":false,"given":"Hugues","family":"Chabriat","sequence":"additional","affiliation":[{"name":"Translational NeuroVascular Centre Lariboisi\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Guey","sequence":"additional","affiliation":[{"name":"Translational NeuroVascular Centre Lariboisi\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-737445"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.269"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0509-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05177.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-021253"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.776"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.3.439"},{"key":"e_1_2_9_9_1","first-page":"427","article-title":"Cerebral MR imaging in intravascular lymphomatosis","volume":"19","author":"Williams RL","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2770"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930515)71:10<3156::AID-CNCR2820711043>3.0.CO;2-O"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940315)73:6<1738::AID-CNCR2820730631>3.0.CO;2-U"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.5414\/NPP26180"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3481-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4391"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01555.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26635"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon199882110"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v10.i12.402"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.01.001"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2023.02.025"},{"key":"e_1_2_9_22_1","first-page":"3363","article-title":"Intravascular large B\u2010cell lymphoma with pontine involvement successfully treated with R\u2010CHOP therapy and intrathecal administration: a case report and review of literature","volume":"7","author":"Sekiguchi Y","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-015-0614-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/4.3.187"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334130"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/BLCTT.S362736"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01613.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10453-5"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-014-1622-z"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(24)00104-2"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008900"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2015-001332"},{"key":"e_1_2_9_33_1","first-page":"239","article-title":"Angiotropic large cell lymphoma with imaging characteristics of CNS vasculitis","volume":"23","author":"Song DK","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2016.06.010"},{"key":"e_1_2_9_35_1","article-title":"Intravascular lymphoma\u2010associated stroke: a systematic review of case studies","volume":"15","author":"Bhagat R","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-230753"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21226"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.606"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.21037\/aol-20-53"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab020"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01378-5"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027008413.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2313"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000268"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.27132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T07:32:57Z","timestamp":1739777577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.27132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/ana.27132"],"URL":"https:\/\/doi.org\/10.1002\/ana.27132","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,28]]},"assertion":[{"value":"2024-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}