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No studies assessed all 3 functions concurrently. We assessed 3 key vascular functions in sporadic and genetic SVD to determine associations with SVD severity, subtype, and interrelations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, cross\u2010sectional, multicenter INVESTIGATE\u2010SVDs study, we acquired brain magnetic resonance imaging in patients with sporadic SVD\/cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), including structural, quantitative microstructural, permeability surface area product, blood plasma volume fraction, vascular pulsatility, and CVR (in response to CO<jats:sub>2<\/jats:sub>) scans. We determined vascular function and white matter hyperintensity (WMH) associations, using covariate\u2010adjusted linear regression; normal\u2010appearing white matter and WMH differences, interrelationships between vascular functions, using linear mixed models; and major sources of variance using principal component analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We recruited 77 patients (45 sporadic\/32 CADASIL) at 3 sites. In adjusted analyses, patients with worse WMH had lower CVR (<jats:italic>B<\/jats:italic>\u2009=\u2009\u22121.78, 95% CI \u22123.30, \u22120.27) and blood plasma volume fraction (<jats:italic>B<\/jats:italic>\u2009=\u2009\u22120.594, 95% CI \u22120.987, \u22120.202). CVR was worse in WMH than normal\u2010appearing white matter (eg, CVR: <jats:italic>B<\/jats:italic>\u2009=\u2009\u22120.048, 95% CI \u22120.079, \u22120.017). Adjusting for WMH severity, SVD subtype had minimal influence on vascular function (eg, CVR in CADASIL vs sporadic: <jats:italic>B<\/jats:italic>\u2009=\u20090.0169, 95% CI \u22120.0247, 0.0584). Different vascular function mechanisms were not generally interrelated (eg, permeability surface area product~CVR: <jats:italic>B<\/jats:italic>\u2009=\u2009\u22120.85, 95% CI \u22124.72, 3.02). Principal component analyses identified WMH volume\/quantitative microstructural metrics explained most variance in CADASIL and arterial pulsatility in sporadic SVD, but similar main variance sources.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Vascular function was worse with higher WMH, and in WMH than normal\u2010appearing white matter. Sporadic SVD\u2010CADASIL differences largely reflect disease severity. Limited vascular function interrelations may suggest disease stage\u2010specific differences. 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