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Participants comprised both cognitively normal and impaired older adults diagnosed with hypertension (n\u2009=\u2009408). All participants underwent comprehensive clinical assessment and [<jats:sup>11<\/jats:sup>C] Pittsburgh Compound B positron emission tomography (PET) for measurement of cerebral \u03b2\u2010amyloid (A\u03b2) deposition. Additionally, a subset of participants (n\u2009=\u2009120) was subjected to [<jats:sup>18<\/jats:sup>F] AV\u20101451 PET to assess tau deposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The AHM group (n\u2009=\u2009227) exhibited significantly lower A\u03b2 deposition (B [SE]\u2009=\u2009\u22120.104 [0.037], <jats:italic>p<\/jats:italic>\u2009=\u20090.006) compared to the non\u2010AHM group (n\u2009=\u2009181), even after controlling for age, sex, apolipoprotein E \u03b54\u2010positivity, vascular risk factors, and mean arterial blood pressure. Further analysis by AHM class showed an association between the use of renin\u2010angiotensin system inhibitors (RASi) and less A\u03b2 deposition (B [SE]\u2009=\u2009\u22120.143[0.049], <jats:italic>p<\/jats:italic>\u2009=\u20090.004). No significant relationships were observed between the use of BBB\u2010permeable AHM and A\u03b2 deposition. Additionally, associations between AHM use and tau deposition did not reach statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>Our findings suggest that AHM use may be associated with lower A\u03b2 burden in older adults with hypertension. Further studies exploring the underlying mechanism, particularly related to RASi, may provide insights into new therapeutic targets for AD. 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