{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:11:30Z","timestamp":1791911490387,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23MH120510"],"award-info":[{"award-number":["K23MH120510"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P50 HD103525"],"award-info":[{"award-number":["P50 HD103525"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["T32HD069038"],"award-info":[{"award-number":["T32HD069038"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["3R01NS114405"],"award-info":[{"award-number":["3R01NS114405"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014370","name":"Simons Foundation Autism Research Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020603","name":"Auxilium Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020603","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Dystonia is a movement disorder defined by involuntary muscle contractions leading to abnormal postures or twisting and repetitive movements. Classically dystonia has been thought of as a disorder of the basal ganglia, but newer results in idiopathic dystonia and lesion\u2010induced dystonia in adults point to broader motor network dysfunction spanning the basal ganglia, cerebellum, premotor cortex, sensorimotor, and frontoparietal regions. It is unclear whether a similar network is shared between different etiologies of pediatric lesion\u2010induced dystonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three cohorts of pediatric patients with lesion\u2010induced dystonia were identified. The lesion etiologies included hypoxia, kernicterus, and stroke versus comparison subjects with acquired lesions not associated with dystonia. Multivariate lesion\u2010symptom mapping and lesion network mapping were used to evaluate the anatomy and networks associated with dystonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate lesion\u2010symptom mapping showed that lesions of the putamen and globus pallidus were associated with dystonia (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Lesion network mapping using normative connectome data from healthy children demonstrated that these regional findings occurred within a common brain\u2010wide network that involves the basal ganglia, anterior and medial cerebellum, and cortical regions that overlap the cingulo\u2010opercular action\u2010mode and somato\u2010cognitive\u2010action networks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>We interpret these findings as novel evidence for a unified dystonia brain network that involves the somato\u2010cognitive\u2010action network, which is implicated in the coordination of movement. Elucidation of this network gives insight into the functional origins of dystonia and provides novel targets to investigate for therapeutic intervention. ANN NEUROL 2025;98:152\u2013162<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.27224","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T06:04:45Z","timestamp":1741673085000},"page":"152-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Network Localization of Pediatric Lesion\u2010Induced Dystonia"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7387-9082","authenticated-orcid":false,"given":"Rose","family":"Gelineau\u2010Morel","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Children's Mercy Kansas City  Kansas City MO"},{"name":"School of Medicine University of Missouri\u2010Kansas City  Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nomazulu","family":"Dlamini","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics The Hospital for Sick Children  Toronto Canada"},{"name":"Faculty of Medicine University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Bruss","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa Carver College of Medicine University of Iowa  Iowa City IA"},{"name":"Department of Neurology, University of Iowa Carver College of Medicine University of Iowa  Iowa City IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-5866","authenticated-orcid":false,"given":"Alexander L.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston Children's Hospital Harvard Medical School  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Robertson","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics The Hospital for Sick Children  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Alexopoulos","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University  St Louis MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Smyser","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University  St Louis MO"},{"name":"Department of Pediatrics Washington University  St Louis MO"},{"name":"Mallinckrodt Institute of Radiology Washington University  St Louis MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-9257","authenticated-orcid":false,"given":"Aaron D.","family":"Boes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Iowa Carver College of Medicine University of Iowa  Iowa City IA"},{"name":"Department of Neurology, University of Iowa Carver College of Medicine University of Iowa  Iowa City IA"},{"name":"Iowa Neuroscience Institute University of Iowa  Iowa City IA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25475"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12339"},{"key":"e_1_2_10_4_1","volume-title":"Bottom line \u2018evidence\u2010informed\u2019 recommendations for the Management of Dystonia in individuals with cerebral palsy","author":"Fehlings D","year":"2016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2018.01.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25532"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.383"},{"key":"e_1_2_10_8_1","first-page":"396","article-title":"New insights into cortico\u2010basal\u2010cerebellar connectome: clinical and physiological considerations","volume":"143","author":"Quartarone A","year":"2020","journal-title":"Brain"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40348-015-0026-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv313"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25527"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201042"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.314574"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-945715"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-024-03453-5"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2016.07.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01570-1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv228"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008326"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac010"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2017.01.016"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1996.0250"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2017.08.027"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116091"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01834-y"},{"key":"e_1_2_10_29_1","volume-title":"GSP1000 preprocessed connectome. V3 ed","author":"Cohen A","year":"2020"},{"key":"e_1_2_10_30_1","volume-title":"bchcohenlab\/BIDS_to_CBIG_fMRI_Preproc2016: first release, all working versions (1.0.0)","author":"Cohen A","year":"2021"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac361"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giy004"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05964-2"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.070"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.027"},{"key":"e_1_2_10_37_1","volume-title":"The brain's cingulo\u2010opercular action\u2010mode network","author":"Dosenbach NUF","year":"2024"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.04.031"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-016-0763-3"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.79135"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102919"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007317"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2021.11.034"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.01.015"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.744503"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/abbbd6"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102569"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738221115248"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105899"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2021.12.004"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz112"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15300"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.27224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T02:02:08Z","timestamp":1750212128000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.27224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/ana.27224"],"URL":"https:\/\/doi.org\/10.1002\/ana.27224","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.06.24305421","asserted-by":"object"}]},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,10]]},"assertion":[{"value":"2024-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}