{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:41:20Z","timestamp":1787856080981,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000381","name":"Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>\n                    Multiple sclerosis (MS) and Alzheimer's disease are neurodegenerative diseases with age\u2010related disability accumulation. In MS, inflammation spans decades, whereas AD is characterized by A\u03b2 plaques and neurofibrillary tangles (NFT). Few studies explore accumulation of amyloids in MS. We examined A\u03b2 deposition and NFT density in temporal and frontal cortices from postmortem MS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200975) and control (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200966) cases. Compared with controls, MS cases showed reduced A\u03b2, especially in those aged &lt;65\u2009years, and reduced NFT, notably in cases aged &gt;65\u2009years. A\u03b2 deposition predicted greater NFT density both in MS cases and controls. MS\u2010related factors may affect A\u03b2\/NFT deposition and\/or clearance, offering new therapeutic insights for both diseases. 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