{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:41:29Z","timestamp":1791805289919,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CIHR, PJT\u2010175056"],"award-info":[{"award-number":["CIHR, PJT\u2010175056"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Doctoral Award"],"award-info":[{"award-number":["Doctoral Award"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["\/\/doi.org\/10.69777\/320890"],"award-info":[{"award-number":["\/\/doi.org\/10.69777\/320890"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000095","name":"Savoy Foundation","doi-asserted-by":"publisher","award":["Doctoral Award"],"award-info":[{"award-number":["Doctoral Award"]}],"id":[{"id":"10.13039\/501100000095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Epilepsy surgery needs predictive features that are easily implemented in clinical practice. Previous studies are limited by small sample sizes, lack of external validation, and complex computational approaches. We aimed to identify and validate visually stereo\u2010electroencephalography (SEEG) features with the highest predictive value for surgical outcome, and assess the reliability of their visual extraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 177 patients with drug\u2010resistant epilepsy who underwent SEEG\u2010guided surgery at 4 epilepsy centers. We assessed the predictive performance of 10 SEEG features from various SEEG periods for surgical outcome, using the area under the receiver operating characteristic curve, and considering resected channels and surgical outcome as the gold standard. Findings were validated externally using balanced accuracy. Six experts, blinded to outcome, evaluated the visual reliability of the optimal feature using interrater reliability, percentage agreement (standard deviation\u2009\u00b1\u2009SD) and Gwet's kappa (\u03ba\u2009\u00b1\u2009SD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The derivation cohort comprised 100 consecutive patients, each with at least 1\u2010year of postoperative follow up (40% temporal lobe epilepsy; 42% Engel Ia). Spatial co\u2010occurrence of gamma spikes and preictal spikes emerged as the optimal predictive feature of surgical outcome (area under the receiver operating characteristic curve 0.82). Applying the optimized threshold from the derivation cohort, external validation in 2 datasets showed similar performances (balanced accuracy 69.2% and 73.2%). Expert interrater reliability for gamma spikes (percentage agreement, 96%\u2009\u00b1\u20092%; \u03ba, 0.63\u2009\u00b1\u20090.16) and preictal spikes (percentage agreement, 92%\u2009\u00b1\u20092%; \u03ba, 0.65\u2009\u00b1\u20090.18) were substantial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Spatial co\u2010occurrence of gamma spikes and preictal spikes predicts surgical outcome. These visually identifiable features may reduce the burden of SEEG analysis by reducing analysis time, and improve outcome by guiding surgical resection margins. ANN NEUROL 2025;98:547\u2013560<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.27278","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T05:28:26Z","timestamp":1750051706000},"page":"547-560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Visual Features in Stereo\u2010Electroencephalography to Predict Surgical Outcome: A Multicenter Study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-6673","authenticated-orcid":false,"given":"Chifaou","family":"Abdallah","sequence":"first","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University Medical Center  Durham North Carolina USA"},{"name":"Department of Biomedical Engineering Duke Pratt School of Engineering  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Aron","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Nancy, Lorraine University  Nancy France"},{"name":"Research Center for Automatic Control of Nancy (CRAN), Lorraine University, CNRS, UMR  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-7978","authenticated-orcid":false,"given":"Tamir","family":"Avigdor","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Biomedical Engineering Duke Pratt School of Engineering  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassem","family":"Jaber","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Duke Pratt School of Engineering  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Dole\u017ealov\u00e1","sequence":"additional","affiliation":[{"name":"Brno Epilepsy Center, First Department of Neurology St. Anne's University Hospital, Faculty of Medicine, Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Mansilla","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital, McGill University  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Neurophysiology Unit, Institute of Neurosurgery Dr. Asenjo  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1300-2323","authenticated-orcid":false,"given":"P\u00e4ivi","family":"Nevalainen","sequence":"additional","affiliation":[{"name":"Epilepsia Helsinki, Full member of ERN EpiCare, Department of Clinical Neurophysiology HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Neurology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaysingh","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-6581","authenticated-orcid":false,"given":"Sandor","family":"Beniczky","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurophysiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Neurophysiology Danish Epilepsy Center  Dianalund Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Kahane","sequence":"additional","affiliation":[{"name":"CHU Grenoble Alpes, Univ. 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