{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:31:48Z","timestamp":1788474708096,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","award":["BRC1287\/TN\/FM\/101410"],"award-info":[{"award-number":["BRC1287\/TN\/FM\/101410"]}],"id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["APVV\u201022\u20100279"],"award-info":[{"award-number":["APVV\u201022\u20100279"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006309","name":"American Parkinson Disease Association","doi-asserted-by":"publisher","award":["1282403"],"award-info":[{"award-number":["1282403"]}],"id":[{"id":"10.13039\/100006309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004229","name":"Fondazione Pierfranco e Luisa Mariani","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG 458949627"],"award-info":[{"award-number":["DFG 458949627"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LO1555\/10\u20101"],"award-info":[{"award-number":["LO1555\/10\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WI 1820\/14\u20101"],"award-info":[{"award-number":["WI 1820\/14\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ZE 1213\/2\u20101"],"award-info":[{"award-number":["ZE 1213\/2\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000304","name":"Parkinson's UK","doi-asserted-by":"publisher","award":["G\u20102401"],"award-info":[{"award-number":["G\u20102401"]}],"id":[{"id":"10.13039\/501100000304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["X22NPO5107"],"award-info":[{"award-number":["X22NPO5107"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015072","name":"Institute for Advanced Study, Technische Universit\u00e4t M\u00fcnchen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The objective was to evaluate the effects of deep brain stimulation (DBS) in an international cohort of patients with\n                      <jats:italic>VPS16<\/jats:italic>\n                      \u2010related dystonia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This observational study collected preoperative and postoperative demographic, clinical, stimulation, genetic, neuroimaging, and neurophysiological data of medically refractory DYT\u2010\n                      <jats:italic>VPS16<\/jats:italic>\n                      patients with implanted DBS in 10 international centers. Motor symptoms and disability outcomes were assessed using the Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale Motor (BFMDRS\u2010M) and Disability (BFMDRS\u2010D) scales. A cut\u2010off threshold for considering response to DBS was set at 25% of BFMDRS\u2010M improvement at the last follow\u2010up (FU) compared to baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort consisted of 26 participants (17 men, 65.4%). Age at dystonia onset and surgery was 17.8\u2009\u00b1\u200910.9 and 35.3\u2009\u00b1\u200914.8\u2009years, respectively. At the last FU, 102.5\u2009\u00b1\u200957.3\u2009months (range, 2\u2013216), the mean BFMDRS\u2010M improvement was 41.6\u2009\u00b1\u200937.3% (26\/26 patients) and 34.8\u2009\u00b1\u200942.6% for the BFMDRS\u2010D (23\/26 patients). Most patients (19\/26, 73%) were considered responders. Higher motor improvement was associated with stimulation of the ventroposterior portion of the internal globus pallidus. A significant inverse relationship was observed between improvement in BFMDRS\u2010M at last FU, and the presence of spasticity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027) and fixed skeletal deformities (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) before surgery. Non\u2010responders had a younger age at disease onset and at implantation, shorter disease duration at DBS surgery, and higher baseline BFMDRS scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>\n                      DBS was an effective treatment for three\u2010quarters of patients with pathogenic\n                      <jats:italic>VPS16<\/jats:italic>\n                      variants in our cohort. Mean motor improvement was most pronounced at the 1\u2010year FU, but persisted at the last FU despite disease progression. ANN NEUROL 2025;98:711\u2013725\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.27290","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:56:59Z","timestamp":1750399019000},"page":"711-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Deep Brain Stimulation for\n                    <scp>\n                      <i>VPS16<\/i>\n                    <\/scp>\n                    \u2010Related Dystonia: A Multicenter Study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5237-8736","authenticated-orcid":false,"given":"Tatiana","family":"Svorenova","sequence":"first","affiliation":[{"name":"Department of Neurology P.J. Safarik University  Kosice Slovak Republic"},{"name":"Department of Neurology University Hospital of L. Pasteur  Kosice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6772-1035","authenticated-orcid":false,"given":"Luigi M.","family":"Romito","sequence":"additional","affiliation":[{"name":"Parkinson and Movement Disorders Unit Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Kaymak","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute Scuola Superiore Sant' Anna  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-8916","authenticated-orcid":false,"given":"Eoin","family":"Mulroy","sequence":"additional","affiliation":[{"name":"Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cif","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gui de Chauliac Hospital University Hospital Montpellier  Montpellier France"},{"name":"Service of Neurology, Department of Clinical Neurosciences Lausanne University Hospital (CHUV) and University of Lausanne (UNIL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7968-5908","authenticated-orcid":false,"given":"Elena","family":"Moro","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University, Division of Neurology, CHU of Grenoble Grenoble Institute of Neurosciences  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten E.","family":"Zeuner","sequence":"additional","affiliation":[{"name":"Department of Neurology Universit\u00e4tsklinikum Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Zittel","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-3840","authenticated-orcid":false,"given":"Jan Niklas","family":"Petry\u2010Schmelzer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Gruber","sequence":"additional","affiliation":[{"name":"Movement Disorders Hospital  Beelitz\u2010Heilst\u00e4tten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesanne","family":"Centen","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"},{"name":"Expertise Center Movement Disorders Groningen University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Albanese","sequence":"additional","affiliation":[{"name":"Department of Neurology IRCCS Fondazione Mondino  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriama","family":"Ostrozovicova","sequence":"additional","affiliation":[{"name":"Department of Neurology P.J. Safarik University  Kosice Slovak Republic"},{"name":"Department of Neurology University Hospital of L. Pasteur  Kosice Slovak Republic"},{"name":"Laboratory of Clinical Neurosciences, University Science Park MEDIPARK P. J. Safarik University  Kosice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology P.J. Safarik University  Kosice Slovak Republic"},{"name":"Department of Neurology University Hospital of L. Pasteur  Kosice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Magocova","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery P.J. Safarik University  Kosice Slovak Republic"},{"name":"Department of Neurosurgery University Hospital of L. Pasteur  Kosice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Knorovsky","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery P.J. Safarik University  Kosice Slovak Republic"},{"name":"Department of Neurosurgery University Hospital of L. Pasteur  Kosice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelia","family":"Kollova","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery P.J. Safarik University  Kosice Slovak Republic"},{"name":"Department of Neurosurgery University Hospital of L. Pasteur  Kosice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Garavaglia","sequence":"additional","affiliation":[{"name":"Unit of Medical Genetics and Neurogenetics Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Golfr\u00e8\u2010Andreasi","sequence":"additional","affiliation":[{"name":"Parkinson and Movement Disorders Unit Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Reale","sequence":"additional","affiliation":[{"name":"Unit of Medical Genetics and Neurogenetics Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Mazzoni","sequence":"additional","affiliation":[{"name":"The BioRobotics Institute Scuola Superiore Sant' Anna  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Department of Child Neurology Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Eleopra","sequence":"additional","affiliation":[{"name":"Parkinson and Movement Disorders Unit Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Levi","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, Functional Neurosurgery Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-1813","authenticated-orcid":false,"given":"Thomas","family":"Foltynie","sequence":"additional","affiliation":[{"name":"Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Limousin","sequence":"additional","affiliation":[{"name":"Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harith","family":"Akram","sequence":"additional","affiliation":[{"name":"Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludvic","family":"Zrinzo","sequence":"additional","affiliation":[{"name":"Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-6245","authenticated-orcid":false,"given":"Francesca","family":"Magrinelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Houlden","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju A.","family":"Kurian","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children UCL Great Ormond Institute of Child Health  London UK"},{"name":"Department of Neurology Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Baiata","sequence":"additional","affiliation":[{"name":"Division of Neurology CHU of Grenoble  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Paschen","sequence":"additional","affiliation":[{"name":"Department of Neurology Universit\u00e4tsklinikum Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5121-1460","authenticated-orcid":false,"given":"Katja","family":"Lohmann","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics University of Luebeck  Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Volkmann","sequence":"additional","affiliation":[{"name":"Department of Neurology University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hamel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Barbe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martje E.","family":"van Egmond","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"},{"name":"Expertise Center Movement Disorders Groningen University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAJ","family":"Tijssen","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"},{"name":"Expertise Center Movement Disorders Groningen University Medical Center Groningen, University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubos","family":"Ambro","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Biosciences, Technology and Innovation Park P.J. Safarik University  Kosice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Jurkova","sequence":"additional","affiliation":[{"name":"Department of Health Psychology and Research Methodology, Faculty of Medicine P.J. Safarik University  Kosice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jech","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charles University in Prague 1st Faculty of Medicine and General University Hospital in Prague  Praha, Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Havrankova","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charles University in Prague 1st Faculty of Medicine and General University Hospital in Prague  Praha, Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Winkelmann","sequence":"additional","affiliation":[{"name":"Institute of Neurogenomics Helmholtz Zentrum M\u00fcnchen  Munich Germany"},{"name":"Institute of Human Genetics, School of Medicine Technical University of Munich  Munich Germany"},{"name":"Munich Cluster for Systems Neurology, SyNergy  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zech","sequence":"additional","affiliation":[{"name":"Institute of Neurogenomics Helmholtz Zentrum M\u00fcnchen  Munich Germany"},{"name":"Institute of Human Genetics, School of Medicine Technical University of Munich  Munich Germany"},{"name":"Institute for Advanced Study Technical University of Munich  Garching Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Skorvanek","sequence":"additional","affiliation":[{"name":"Department of Neurology P.J. Safarik University  Kosice Slovak Republic"},{"name":"Department of Neurology University Hospital of L. Pasteur  Kosice Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25879"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28540"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25834"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.12"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13392"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28647"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25990"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000202761"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000644"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/aian.aian5923"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-023-00720-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1198821"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13927"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-322169"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-016-1656-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02410-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001312"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.08.034"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.09.022"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13374"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.19006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurom.2023.10.187"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.630391"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12124"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1011"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1061"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.35.1.73"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.06.023"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29815"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.08.068"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2114985119"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz046"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.27185"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29327"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-022-00185-w"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdbs.2024.10.001"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10863-5"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063618"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00547"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa304"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyab095"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000002836"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307074110"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.109694"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24187"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.27290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:14:53Z","timestamp":1761131693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.27290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ana.27290"],"URL":"https:\/\/doi.org\/10.1002\/ana.27290","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"assertion":[{"value":"2025-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}