{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T06:01:49Z","timestamp":1705298509237},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":10141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lumbar cerebrospinal fluid (CSF) norepinephrine concentrations determined by radioenzymatic assay in 9 patients with caudate atrophy associated with Huntington's disease were lower (<jats:italic>p<\/jats:italic> &lt; 0.02) than those in 9 age\u2010 and sex\u2010matched control patients.<\/jats:p><jats:p>Preoperative lumbar CSF norepinephrine concentrations were determined in 5 patients undergoing stereotaxic thalamotomy. No significant alterations in prestimulation lumbar CSF norepinephrine levels were recorded 12 days after electrode installation and thalamic coagulation. Lumbar CSF norepinephrine concentrations were reduced (<jats:italic>p<\/jats:italic> &lt; 0.03), however, 12 hours following intermittent selective electrical stimulation of the caudate nucleus.<\/jats:p><jats:p>These data suggest that noradrenergic pathways in man are (1) impaired in Huntington's disease and (2) inhibited by direct caudate stimulation.<\/jats:p>","DOI":"10.1002\/ana.410010110","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:05:02Z","timestamp":1104584702000},"page":"94-99","source":"Crossref","is-referenced-by-count":11,"title":["Cerebrospinal fluid norepinephrine reductions in man after degeneration and electrical stimulation of the caudate nucleus"],"prefix":"10.1002","volume":"1","author":[{"given":"James H.","family":"Wood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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