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Propranolol had no effect on tremor frequency (6 to 8 cps), but it suppressed tremor amplitude in all patients in direct proportion to the drug's plasma concentration and to the intensity of beta\u2010adrenergic blockade produced. Among this group of patients the maximal tremor decrease occurred at plasma levels of about 100 ng per milliliter and varied widely between individuals (18 to 85%), implying that the efficacy of propranolol therapy in essential tremor depends on both the plasma drug level and the innate sensitivity of the disorder in the individual patient.<\/jats:p>","DOI":"10.1002\/ana.410010210","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:58:41Z","timestamp":1104587921000},"page":"160-166","source":"Crossref","is-referenced-by-count":41,"title":["Suppression of essential tremor by propranolol: Correlation of effect with drug plasma levels and intensity of beta\u2010adrenergic blockade"],"prefix":"10.1002","volume":"1","author":[{"suffix":"Jr.","given":"R. 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